Naphthalene -Diselenide-Based BODIPY Probe for the Detection of Hydrogen Peroxide, Butylhydroperoxide, Hydroxyl Radical, and Peroxynitrite Ion.

Dimethoxynaphthalene peri-diselenide-based BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) probe has been synthesized. The probe demonstrated selectivity and sensitivity for hydrogen peroxide (HO) and butylhydroperoxide (BuOOH), hydroxyl radical (OH), and peroxynitrite ion (ONOO) detection and reversibility upon treatment with glutathione. The limits of detection of the probe were observed to be 0.

Radical-Trapping and Hydroperoxide-Decomposing Benzoselenazole Antioxidants with Potential Biological Applications against Oxidative Stress.

The synthesis of phenolic benzoselenazoles has been described. These were synthesized from their corresponding diselenides and aldehydes using acetic acid as a catalyst. All compounds have been tested for glutathione peroxidase (GPx)-like antioxidant activity in thiophenol assay.

Aminic Organoselenium Compounds as Glutathione Peroxidase Mimics and Inhibitors of Ferroptosis.

The synthesis of diarylamine-based organoselenium compounds via the nucleophilic substitution reactions has been described. Symmetrical monoselenides and diselenides were conveniently synthesized by the reduction of their corresponding selenocyanates using sodium borohydride. Selenocyanates were obtained from 2-chloro acetamides by the nucleophilic displacement with potassium selenocyanate.

Synthesis, Reactions, and Antioxidant Properties of Bis(3-amino-1-hydroxybenzyl)diselenide.

Bis(3-amino-1-hydroxybenzyl)diselenide containing two groups was synthesized from 7-nitro-3-2,1-benzoxaselenole and in situ generated sodium benzene tellurolate (PhTeNa). One-pot synthesis of 1,3-benzoselenazoles was achieved from bis(3-amino-1-hydroxybenzyl)diselenide and aryl aldehydes using acetic acid as a catalyst. The X-ray crystal structure of chloro-substituted benzoselenazole revealed a planar structure with T-shaped geometry around the Se atom.