Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance.

Fibroblast growth factor 15/19 (FGF15/19, mouse/human ortholog) is expressed in the ileal enterocytes of the small intestine and released postprandially in response to bile acid absorption. Previous reports of FGF15-/- mice have limited our understanding of gut-specific FGF15's role in metabolism. Therefore, we studied the role of endogenous gut-derived FGF15 in bile acid, cholesterol, glucose, and energy balance.

Liouvillian exceptional points of an open driven two-level system.

We study the applicability of the Liouvillian exceptional points (LEPs) approach to nanoscale open quantum systems. A generic model of the driven two-level system in a thermal environment is analyzed within the nonequilibrium Green's function (NEGF) and Bloch quantum master equation formulations. We derive the latter starting from the exact NEGF Dyson equations and highlight the qualitative limitations of the LEP treatment by examining the approximations employed in its derivation.