Publications by authors named "Nikhil Khandale"
Nanoparticulate drug delivery systems (NDDS) based nanoformulations have emerged as promising drug delivery systems. Various NDDS-based formulations have been reported such as polymeric nanoparticles (NPs), nanoliposomes, solid lipid NPs, nanocapsules, liposomes, self-nano emulsifying drug delivery systems, pro liposomes, nanospheres, microemulsion, nanoemulsion, gold NPs, silver NPs and nanostructured lipid carrier. They have shown numerous advantages such as enhanced bioavailability, aqueous solubility, permeability, controlled release profile, and blood-brain barrier (BBB) permeability.
View Article and Find Full Text PDFAlzheimer's disease (AD) is the most prevalent form of neurodegenerative disorder (ND), affecting more than 44 million individuals globally as of 2023. It is characterized by cognitive dysfunction and an inability to perform daily activities. The progression of AD is associated with the accumulation of amyloid beta (Aβ), the formation of neurofibrillary tangles (NFT), increased oxidative stress, neuroinflammation, mitochondrial dysfunction, and endoplasmic reticulum stress.
View Article and Find Full Text PDFArticle Synopsis
- - Recent studies highlight the gut microbiome's crucial role in human health, linking it to various diseases, including neurodegenerative diseases (ND), and indicating potential therapeutic applications.
- - The article examines how post-biotics could protect against ND by increasing dopamine levels, reducing harmful proteins, and improving motor function while also lowering inflammation and apoptosis.
- - It consolidates findings from preclinical and clinical trials that support the neuroprotective effects of post-biotics, showcasing their antioxidant abilities and potential for enhancing overall health in the context of ND.