Comparison of multiple modalities for drug response prediction with learning curves using neural networks and XGBoost.

Motivation: Anti-cancer drug response prediction is a central problem within stratified medicine. Transcriptomic profiles of cancer cell lines are typically used for drug response prediction, but we hypothesize that proteomics or phosphoproteomics might be more suitable as they give a more direct insight into cellular processes. However, there has not yet been a systematic comparison between all three of these datatypes using consistent evaluation criteria.