Publications by authors named "Niketa Pawar"

Article Synopsis
  • Chronic metabolic overload from saturated fatty acids like palmitate leads to insulin resistance in muscle cells, largely due to the synthesis of ceramide.
  • The study found that treatment with palmitate increased the expression of nSMase genes linked to ceramide production, while inhibition of nSMase using GW4869 improved insulin sensitivity and metabolic function in muscle cells.
  • Inhibiting nSMase also reduced oxidative and endoplasmic reticulum stress, suggesting that it can help protect against lipotoxicity and related inflammatory responses in skeletal muscle.
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