Publications by authors named "Nijiati Muyesai"
Objective: To assess the association between the systemic inflammation response index (SIRI) and the prognosis in patients with sepsis-associated acute kidney injury (SA-AKI).
Methods: In this observational study, adult patients with SA-AKI were categorized into three groups based on SIRI tertiles. Survival outcomes were compared across the three groups using Kaplan-Meier survival curves.
Background: Skull fracture can lead to significant morbidity and mortality, yet the development of effective predictive tools has remained a challenge. This study aimed to establish and validate a nomogram to evaluate the 28-day mortality risk among patients with skull fracture.
Materials And Methods: Data extracted from the Medical Information Mart for Intensive Care (MIMIC) database were utilized as the training set, while data from the eICU Collaborative Research Database were employed as the external validation set.
Purpose: To investigate the optimal target temperature of cooling intervention in heat stroke (HS) rats and explore the potential mechanisms of cooling intervention in alleviating heat stroke-induced damage.
Materials And Methods: A total of 32 Sprague-Dawley rats were randomly divided into 4 groups (n=8/group), including control, HS[core body temperature (Tc)], HS(Tc-1°C) and HS(Tc+1°C) group. Heat stroke model was established in rats of HS(Tc), HS(Tc-1°C) and HS(Tc+1°C) group.
Background: Elevated glucose levels at admission are associated with a worse prognosis in patients with acute myocardial infarction (AMI); additionally, such elevation has a higher prognostic value for patients without diabetes.
Methods: We retrospectively recruited 2412 AMI patients without diabetes from 1 August 2011 to 10 January 2022. The primary outcome was all-cause mortality during hospitalisation, and the secondary outcomes were cardiogenic shock, ventricular tachycardia, ventricular fibrillation, atrioventricular block and new stroke.
Background: Acute Myocardial Infarction (AMI) is a kind of cardiovascular disease with high mortality and incidence. Extracellular vesicles (EVs) and microRNA-126 (miR-126) are known to play important role in the development and prognosis of several cardiovascular diseases. Therefore, this study aimed to investigate the changes in Extracellular vesicle (EV)-associated miR-126 levels in the coronary blood of patients with AMI to explore the relationship between miR-126 levels and AMI.
View Article and Find Full Text PDFBackground: Little is known about the predictive value of soluble AXL (sAXL) in heart failure (HF). This study aimed to describe the prognostic value of plasma sAXL in patients with symptomatic HF.
Methods: This is a multicentre observational prospective cohort study (Registration No.
Background: Acute myocardial infarction (AMI) is the leading cause of death for patients with cardiovascular disease (CVD). Although researchers have made substantial efforts to elucidate its pathogenesis, the molecular mechanisms underlying AMI remain unknown. The aim of this study was to use proteomics to identify differentially expressed proteins (DEPs) and the possible biological functions and metabolic pathways related to coronary blood microparticles (MPs) in patients with AMI and stable coronary artery disease (SCAD); this study will allow for the identification of individuals at risk of acute thrombosis.
View Article and Find Full Text PDFPurpose: Acute aortic syndrome is a constellation of life-threatening medical conditions for which rapid assessment and targeted intervention are important for the prognosis of patients who are at high risk of in-hospital death. The current study aims to develop and externally validate an early prediction mortality model that can be used to identify high-risk patients with acute aortic syndrome in the emergency department.
Patients And Methods: This retrospective multi-center observational study enrolled 1088 patients with acute aortic syndrome admitted to the emergency departments of two hospitals in China between January 2017 and March 2021 for model development.
Background: Mounting evidence suggests that endothelial cell-derived microparticles (EMPs) and red blood cell-derived microparticles (RMPs), which have procoagulant and vasoconstriction effects, are involved in the development of vascular acute cardiovascular events. The aim of this study was to analyze the circulating levels of EMPs and RMPs in patients with acute myocardial infarction (AMI), and to explore the correlations between EMPs and RMPs and the severity of coronary artery disease.
Methods: Plasma samples from 110 patients with AMI and 57 non-coronary artery disease group (nonCAD) were collected in the present study.
Background: To observe the thrombogenic activity of platelet-derived microparticles (PMPs) in PMP-free plasma from non-coronary artery disease (non-CAD) patients and explore the relationship between PMPs and thrombosis in acute coronary syndrome (ACS) patients.
Methods: Patients with ACS who were diagnosed at the outpatient department of cardiology in the People's Hospital of Xinjiang Uygur Autonomous Region, and non-CAD subjects were enrolled in the study from January 2011 to December 2014. Subjects were assigned to the ACS group (n=200) (which consisted of patients with acute myocardial infarction (AMI, n=100) and patients with unstable angina pectoris) (UAP, n=100), or to the non-CAD group (n=100).
Background: A limited number of reports are analyzing the etiology and the mechanism of coronary heart disease by examining the source cells of micro particles (MPs) in coronary heart disease patients with percutaneous coronary intervention (PCI). This study aims to explore the circulating platelet micro particles (PMPs) content variation in the blood stream and the mechanism of MPs-inducing thrombosis in patients operated with coronary stenting, with the intent to analyze the impact of PMPs on thrombosis and in-stent restenosis.
Methods: 3000 patients with coronary heart disease were successfully operated with PCI.
Background: The aim of this study was to analyze the relationships between the endothelial cell micro-particles (EMPs) blood level and the blood lipid in Uygur and Han patients with acute coronary syndrome (ACS) in order to provide a theoretical basis for the pathogenesis study of ACS.
Methods: 100 ACS patients (50 cases for each ethnic group) were selected as the patient group from January 2012 to August 2013 from the Cardiology Sector of the People's Hospital of the Xinjiang Uygur Autonomous Region, and 100 healthy subjects (50 cases for each ethnic group) were selected as the control group. Blood samples were collected.
Background: In centenarian populations, application of the positive biology approach (examination of positive phenotypes in aging) has revealed that mitochondrial DNA (mtDNA) mutation accumulation may be linked to human longevity; however, the role of guanine nucleotide-binding protein (G protein) abnormalities modulated by G-protein beta-3 (GNB3) and nitrate (NO2) production associated with endothelial nitric oxide synthase (eNOS), commonly appearing in age-related diseases, remains undetermined.
Objective: The association between the mtDNA 5178A/C, mtDNA 10398A/G, GNB3 C825T, and eNOS polymorphisms and longevity in a Uygur population (Xinjiang region, China) were investigated.
Methods: A total of 275 experimental subjects aged ≥ 100 or with 4 generations currently living were screened for inclusion in the centenarian (>100 years) and nonagenarian groups (90-100 years), and 112 65-70 year old control subjects were selected.
Objective: To explore the sociodemographic patterning of risk factors for cardiovascular disease (CVD) in three isolated-based subgroups of the Uyghur population in Xinjiang, China.
Design: A cross-sectional study. Between 2005 and 2008, a non-probability sampling design method was used to select three specific groups of the Uyghur rural populations based on their potential socioeconomic status (ie, isolated, semi-isolated and open-environment status).
[Investigation on physiological characteristics in "offspring of Lop Nor people"].
Beijing Da Xue Xue Bao Yi Xue Ban
August 2011
Objective: To investigate the physiological characteristics in "offspring of Lop Nor people", a special population from the Lop Nor dried up in Xinjiang.
Methods: A total of 594 subjects were selected by convenience sampling method from Yuli County, Xinjiang Uygur Autonomous Region. All data were obtained from each person by the questionnaire and standard physical examinations.