Publications by authors named "Nijia Chang"

Article Synopsis
  • LINC01134 is a long noncoding RNA that reduces cell viability and promotes resistance to oxaliplatin (OXA) in hepatocellular carcinoma (HCC) by interacting with the antioxidant stress pathway, specifically through GPX4.
  • The study used various methods, including bioinformatics, Western blot, and transfection assays, to show that silencing LINC01134 increases OXA sensitivity by altering levels of reactive oxygen species (ROS) and other cellular markers.
  • The research highlights the importance of the LINC01134/Nrf2/GPX4 axis in HCC, suggesting that targeting these components could represent a promising approach for HCC treatment.
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An immunoscore for colorectal cancer (CRC) has higher prognostic significance than the TNM staging system. However, the tumor immune microenvironment contains various components that affect clinical prognosis. Therefore, a broader range of immune markers is required to establish an accurate immunoprofile to assess the prognosis of patients with CRC.

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The present study aimed to investigate the clinical characteristics and outcomes of patients with advanced non-small cell lung cancer (NSCLC) treated with osimertinib, and focused on the resistance mechanism to osimertinib in a real-world setting. Data from 128 patients with advanced NSCLC who were treated with osimertinib between March 2015 and November 2018 at the Chinese People's Liberation Army General Hospital (Beijing, China) were retrospectively collected, and the associations between mutation types and survival were analysed. In patients treated with osimertinib, the objective response rate reached 60.

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