Effects of carbohydrate polymers in self-microemulsified tablets on the bioavailability of atorvastatin: In vitro-in vivo study.

Aims: The concentrations of crospovidone (CP), maltodextrin and microcrystalline cellulose (MCC) have been optimized in the development of self-microemulsified tablets (SMET) to improve the oral bioavailability of an anti-hyperlipidemic drug, atorvastatin, and the in-vivo pharmacokinetic parameters of the optimized SMET were compared with those of a commercial tablet in rabbits.

Main Methods: Self microemulsified liquids (SELS) were prepared with oleic acid, Span 40 and Tween 80. SELS were converted into SMET by adsorption, followed by compression using factors such as CP, maltodextrin and MCC, which were optimized through a 2(3)-factorial design considering responses such as the disintegration time and, the times for 50% and 80% of the drug to be released.

Microemulsion based topical hydrogel of sertaconazole: formulation, characterization and evaluation.

A microemulsion (ME) based hydrogel had studied as a topical delivery of sertaconazole (STZL) for effective eradication of cutaneous fungal infection. The existence of microemulsion region was investigated in pseudo-ternary phase diagrams and various ME formulations were prepared using oleic acid, Tween 80, propylene glycol and water. Hydrogel of STZL microemulsions (HSM) were prepared in Carbopol 940 (0.

Effect of microemulsion in topical sertaconazole hydrogel: in vitro and in vivo study.

Purpose: A topical microemulsion (ME)-based hydrogel was developed to enhance permeation of an antifungal drug, sertaconazole (STZL) for effective eradication of cutaneous fungal infection.

Methods: Pseudo-ternary phase diagrams were used to determine the existence of MEs region. ME formulations were prepared with oleic acid, Tween 80, propylene glycol (PG) and water.

Optimization of HPMC and carbopol concentrations in non-effervescent floating tablet through factorial design.

This study was to optimize HPMC K4M and carbopol 934 concentration in the development of non-effervescent floating tablets (NEFTs) of glipizide as model drug using 3(2) factorial design. The time required for releasing drug of 50% and 80% and similarity factor were the target responses. HPMC K4M and carbopol 934 concentrations were the variables.

Development and validation of RP-HPLC method for quantification of glipizide in biological macromolecules.

Glipizide (GPZ) has been widely used in the treatment of type-2 diabetics as insulin secretogague. Multiunit chitosan based GPZ floating microspheres was prepared by ionotropic gelation method for gastroretentive delivery using sodiumtripolyphosphate as cross-linking agent. Pharmacokinetic study of microspheres was done in rabbit and plasma samples were analyzed by a newly developed and validated high-performance liquid chromatographic method.

Development and validation of analytical method for the estimation of nateglinide in rabbit plasma.

Nateglinide has been widely used in the treatment of type-2 diabetics as an insulin secretogoga. A reliable, rapid, simple and sensitive reversed-phase high performance liquid chromatography (RP-HPLC) method was developed and validated for determination of nateglinide in rabbit plasma. The method was developed on Hypersil BDSC-18 column (250 mm×4.

Compatibility studies of nateglinide with excipients in immediate release tablets.

Experiments were done to assess the compatibility of nateglinide with selected excipients in the development of immediate release tablets of nateglinide by thermal and isothermal stress testing (IST) techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric (DSC) study, infra-red (IR) spectrophotometric study and isothermal stress testing were adopted. The results of DSC study showed that magnesium stearate exhibited some interaction with nateglinide.