Tau protein is differentially phosphorylated in young- and old-aged rats with experimentally induced hyperthyroidism.

Aim: Aging involves progressive physiological changes, including thyroid dysfunction; thus, changes in plasma thyroid hormone (TH) level may affect neuronal function such as synaptic plasticity and Tau phosphorylation. However, how Tau protein is modulated in hyperthyroidism with aging is not clear. To clarify this issue, long-term potentiation (LTP) and accompanying phosphorylation of Tau protein in different residues were investigated in the hippocampus of young and old rats with experimentally induced hyperthyroidism.