Cyclodextrin modified biocompatible Chitosan-Cinnamaldehyde Schiff base hydrogels: Their antibacterial, antioxidant, and drug delivery potential.

Chitosan (CS)-based hydrogels are promising platforms for drug delivery owing to their biocompatibility, biodegradability, and functional versatility. However, pure CS Schiff base hydrogels lack mechanical strength and rely on toxic cross-linkers, necessitating bio-safe alternatives viz. Cinnamaldehyde (CA).

Fungicide-albumin interactions: unraveling the complex relationship-a comprehensive review.

This review will give an insight into the interactions of serum albumins, which are proteins found in the blood, with fungicides. There are molecular interactions between several fungicides and two serum albumin proteins: human serum albumin (HSA) and bovine serum albumin (BSA). The main objective of this review is to through some light on the interactions of the fungicides with serum albumins and to highlight their toxicity level.

Bergenia stracheyi extract-based hybrid hydrogels of biocompatible polymers with good adhesive, stretching, swelling, self-healing, antibacterial, and antioxidant properties.

An ultra-stretchable, quickly self-healable, adhesive hydrogel with efficient anti-oxidant and anti-bacterial activities makes it potential wound dressing material, particularly in healing skin wounds. However, it is highly challenging to prepare such hydrogels with a facile and efficient material design. Given this, we opine the synthesis of medicinal plant Bergenia stracheyi extract-loaded hybrid hydrogels of biocompatible and biodegradable polymers like Gelatin, Hydroxypropyl cellulose, and Polyethylene glycol with acrylic acid via in situ free radical polymerization reaction.

pH Changes in the Micelle-Water Interface of Surface-Active Ionic Liquids Dictate the Stability of Encapsulated Curcumin: An Insight Through a Unique Interfacial Reaction between Arenediazonium Ions and -Butyl Hydroquinone.

The chemical kinetic (CK) method, which involves the reduction of 4-hexadecylbenzenediazonium ions (16-ArN ) by antioxidants (in the present case, TBHQ) occurring exclusively at the interface of the association colloids, was employed to establish the changes in the chemical reactivity of anionic surface-active ionic liquids (SAILs) as a function of the concentration and the composition in their mixed states. We used sodium dodecyl sulfate and different SAILs based on the dodecylsulfate surfactant containing 1-alkyl-3-methylimidazolium cations as counterions having a varying alkyl chain length of 4 (bmim), 8 (omim), and 12 (ddmim) carbon atoms. The structural transitions of aggregates of the SAILs from the micellar to vesicular form were observed as a function of concentration in single surfactant systems and as a function of composition in mixed surfactant systems.

Emission Color Tuning and White Light Generation from a Trimolecular Cocktail in Cationic Micellar System with Promising Applicability in the Anticounterfeiting Technology.

The development of photoluminescent (PL) systems, displaying multiple stimuli-responsive emission color tuning, has been the pressing priority in the recent times due to their huge role in contemporary lighting and anticounterfeiting technologies. Acknowledging this importance, we present a simple and eco-friendly PL system showing emission color tuning in response to different stimuli, that is, the composition of the system, pH, excitation wavelength, and the temperature with the plus point of getting significantly pure white light emission (WLE). The novel system is fabricated from the aqueous mixture of three organic fluorophores, umbelliferone (), fluorescein (), and Rhodamine-B ().

Exploiting self-assembled soft systems based on surfactants, biopolymers and their mixtures for inhibition of Citral degradation under harsh acidic Conditions.

The chemical instability of Citral in acidic conditions is viewed as hurdle to commercialize it in food/beverage industries. We attempted to stabilize citral in various single and mixed surfactant systems at pH 1.0 and temperature 25 °C.

Aggregation and Rheological Behavior of the Lavender Oil-Pluronic P123 Microemulsions in Water-Ethanol Mixed Solvents.

The effect of lavender oil on aggregation characteristics of P123 in aqueous-ethanolic solutions is investigated systematically by DLS, SANS, and rheology. The solubilization capacity of the P123 based formulations toward Lavender oil increased by increasing P123 concentration. The study unveiled the importance of the short chain alcohol-ethanol, as solubilization enhancer.

A novel combined chemical kinetic and trapping method for probing the relationships between chemical reactivity and interfacial HO, Br and H ion molarities in CTAB/CE mixed micelles.

A delicate balance-of-forces governs the interactions responsible for surfactant self-assembly and chemical reactivity within them. Chemical reactions in micellar media generally occur in the interfacial region of micelles that is a complex mixture of: water, headgroups, counterions, co-ions, acids or bases, organic solvents, and the reactants themselves. We have carried out a detailed study of a complex chemical reaction in mixed CTAB/CE micelles by using the chemical kinetic (CK) and chemical trapping (CT) methods.

Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis.

Bergenin pentacetate (2), a peracetate derivative of biologically active lead compound Bergenin (1) isolated from Bergenia stracheyi was subjected to lipase catalyzed regioselective alcoholysis to obtain 3,4,10,11-tetracetate of Bergenin (3). The free hydroxyl group of 3 was derivatised using higher carboxylic acids to obtain acyl derivatives (4-7). These compounds synthesized via chemoenzymatic route were characterized using 1H NMR, 13C NMR and mass spectral data and evaluated for DPPH radical scavenging, antimicrobial and xanthine oxidase inhibitory activities.

New isoflavones from Iris kashmiriana.

Phytochemical investigation of the rhizomes of Iris kashmiriana (Iridaceae) led to the isolation of three isoflavones characterized by 1D and 2D NMR, IR, UV, and MS as 4'-hydroxy-8-methoxy-6,7-methylenedioxyisoflavone (isonigricin, 1), 5,6-dihydroxy-4',7-dimethoxyisoflavone (isoirisolidone, 2), and 5,7-dihydroxy-4',6-dimethoxyisoflavone (irisolidone, 3). Compound 1 is a new isoflavone, while 2 is reported for the first time from a natural source.

Immunomodulatory activity of isoflavones isolated from Iris germanica (Iridaceae) on T-lymphocytes and cytokines.

The immunomodulatory activities of two isoflavones, 5,7-dihydroxy-6,4'-dimethoxyisoflavone (irisolidone) (1) and 5,4'-dihydroxy-6,7-methylenedioxyisoflavone (irilone) (2) isolated from Iris germanica (Iridaceae) is reported. Their influence on production of T-lymphocytes (CD4+ and CD8+ cells) and T-cell cytokines, namely Th1: IL-2, IFN-gamma and Th2: IL-4 and IL-5 in a dose-dependent manner was studied by flow cytometric method in Balb/c mice. Oral administration of drugs at doses of 0.

Immunomodulatory effect of bergenin and norbergenin against adjuvant-induced arthritis--a flow cytometric study.

Bergenin (1), a C-glycoside of 4-O-methyl gallic acid, isolated from rhizomes of Bergenia stracheyi (Saxifragaceae) and its O-demethylated derivative norbergenin (2), prepared from 1, are reported to show anti-arthritic activity through possible modulation of Th1/Th2 cytokine balance. Flow cytometric study showed that the oral administration of 1 and 2 at doses of 5, 10, 20, 40 and 80 mg/kg per oral dose inhibit the production of proinflammatory Th1 cytokines (IL-2, IFN-gamma and TNF-alpha) while as potentiate anti-inflammatory Th2 cytokines (IL-4 and IL-5) in the peripheral blood of adjuvant-induced arthritic balb/c mice. This shows the potential Th1/Th2 cytokine balancing activity of 1 and 2 which is strongly correlated with their anti-arthritic activity.