Publications by authors named "Nighat Ara"
Article Synopsis
- * Methods: Conducted at a diagnostic hospital in Rawalpindi, Pakistan, the study involved analyzing challenging biopsy specimens using various staining techniques and had two observers provide preliminary and final diagnoses without prior knowledge of each other's reports.
- * Results: The application of the two staining methods resulted in a significant reduction in differences between observers, enhancing the diagnosis of microinvasive oral squamous cell carcinoma by revealing details that normal staining missed.
Background: Lip and oral squamous cell carcinoma maintains a significant disease burden in Pakistan. The latest research on cancer focuses more on the role of body's immune response in tumour progression and spread rather than on the nature of neoplastic cells. Tumour-infiltrating lymphocytes constitute a major part of the tumour microenvironment and infiltration of tumour stroma by cytotoxic T-cells are known to limit the tumour progression in various malignancies, such as colorectal and stomach cancers.
View Article and Find Full Text PDFBackground: Carcinomas of the salivary gland are known to be aggressive in nature, making them difficult to manage. The therapeutic options offered include excision of the gland (maxillectomy in cases of palatal tumours), with or without lymph node dissection, proceeded with radiotherapy. Chemotherapy has not produced promising outcomes and has a minimal impact as a therapeutic alternative.
View Article and Find Full Text PDFBackground: Eventually Oral submucous fibrosis causes pronounced stiffness and failure to open the mouth. Objectives are to determine compare the efficacy of intralesional steroids alone and combination of steroids with hyaluronidase on mouth opening in oral submucous fibrosis.
Methods: It was a prospective comparative cohort study.
Objective: The objective of this study was to determine the Immunohistochemical expression of PD- 1, PD-L1 and its association with nodal metastasis in head and neck squamous cell carcinoma.
Materials And Methods: A total of 66 cases were studied at Oral pathology/Histopathology, Armed forces Institute of Pathology (AFIP), Rawalpindi. The tissue sampling and processing yielded the formalin fixed, paraffin wax blocks.
Objective: To compare mast cell and microvessel densities among histologic grades of oral squamous cell carcinoma.
Setting: Armed Forces Institute of Pathology.
Materials And Methods: A total of 60 specimens of OSCC comprising 20 each of well, moderately and poorly differentiated were evaluated.
Frequency of p53 gene mutation and protein expression in oral squamous cell carcinoma.
J Coll Physicians Surg Pak
October 2014
Objective: To determine the frequency of p53 gene mutation and protein expression in Oral Squamous Cell Carcinoma (OSCC) and to establish correlation between the two.
Study Design: Analytical study.
Place And Duration Of Study: Histopathology Department and Molecular Biology Laboratory, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from May 2010 to May 2011.
Objectives: Very few studies have examined mental health morbidity in Bangladesh. This community-based study of rural Bangladesh in 2000-2001 estimated the burden of mental morbidity among rural people of working age.
Study Design And Methods: Community surveys were conducted with one respondent from each household of three selected villages in the service provision area of a non-profit public health organization.