Optimal storage temperature and matrix before analyzing mycophenolic acid.

Background: The immunosuppressant mycophenolic acid (MPA) is widely used in solid organ transplantation and increasingly in hematological conditions and autoimmune disease. Concentration monitoring is generally restricted to specialist laboratories associated with transplant centers to which samples are referred, and delays in transit may occur both from the patient to the local laboratory and from there to the specialist laboratory. The instability of the mycophenolate glucuronides in plasma is well described, but the data on MPA stability in patient samples are limited, particularly in whole blood.

Monitoring mycophenolate in liver transplant recipients: toward a therapeutic range.

Predose plasma mycophenolic acid (MPA) concentrations measured with a semi-automated enzyme-multiplied immunoassay were related to adverse events (e.g., rejection, leukopenia, infection), drug dose, and clinical status in 147 adult and 63 pediatric liver allograft recipients receiving adjunctive immunosuppression with mycophenolate mofetil (MMF).