Medial Ulnar Collateral Ligament Reconstruction With Allograft Provides Excellent Clinical Outcomes, High Rates of Return to Play, and a Low Incidence of Postoperative Complications: A Systematic Review.

Purpose: To perform a systematic review evaluating clinical outcomes in patients undergoing medial ulnar collateral ligament reconstruction (MUCLR) with soft-tissue allograft.

Methods: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary outcomes evaluated were patient-reported outcome scores, return to play (RTP) rates, incidence of postoperative complications, and rates of graft rupture or mechanical failure.

Medial Collateral Ligament Reconstruction With Autograft Versus Allograft: A Systematic Review.

Background: Medial collateral ligament (MCL) reconstruction (MCLR) is performed after failed nonoperative treatment or high-grade MCL injury with associated valgus instability.

Purpose: To evaluate clinical outcomes after MCLR with autograft versus allograft.

Study Design: Systematic review, Level of evidence, 4.

Integrated machine learning pipeline for aberrant biomarker enrichment (i-mAB): characterizing clusters of differentiation within a compendium of systemic lupus erythematosus patients.

Clusters of differentiation () are cell surface biomarkers that denote key biological differences between cell types and disease state. CD-targeting therapeutic monoclonal antibodies () afford rich trans-disease repositioning opportunities. Within a compendium of systemic lupus erythematous () patients, we applied the Integrated machine learning pipeline for aberrant biomarker enrichment () to profile gene expression features affecting CD20, CD22 and CD30 gene aberrance.