Objectives: While patient input to health technology assessment (HTA) has traditionally been of a qualitative nature, there is increasing interest to integrate quantitative evidence from patient preference studies into HTA decision making. Preference data can be used to generate disease-specific health utility data. We generated a health utility score for patients with chronic obstructive pulmonary disease (COPD) and consider its use within HTAs.
View Article and Find Full Text PDFThe large Weilasituo Sn-polymetallic deposit is a recent exploration discovery in the southern Great Xing'an Range, northeast China. The ore cluster area shows horizontal mineralization zoning, from the inner granite body outward, consisting of high-T Sn-W-Li mineralization, middle-T Cu-Zn mineralization and peripheral low-T Pb-Zn-Ag mineralization. However, the intrinsic genetic relationship between Sn-W-Li mineralization and peripheral vein-type Pb-Zn-Ag-Cu mineralization, the formation mechanism and the deep geological background are still insufficiently understood.
View Article and Find Full Text PDFActa Crystallogr B Struct Sci Cryst Eng Mater
December 2023
Density functional theory methods are applied to crystal structures and stabilities of phases from the aleksite homologous series, PbBiTeS (n = homologue number). The seven phases investigated correspond to n = 0 (tetradymite), 2 (aleksite-21R and -42R), 4 (saddlebackite-9H and -18H), 6 (unnamed PbBiTeS), 8 (unnamed PbBiTeS), 10 (hitachiite) and 12 (unnamed PbBiTeS). These seven phases correspond to nine single- or double-module structures, each comprising an odd number of atom layers, 5, 7, (5.
View Article and Find Full Text PDFThe contentious issue of cow-calf separation at birth is incongruent with many views on acceptable farming practices, and carries the risk of eroding public trust in the dairy industry if it is not addressed. The available evidence provides little support for the practice, but research on best practices for maintaining cow-calf contact in a way that enhances animal welfare while preserving farm profitability is nascent. In this article, the authors address the research questions that require answers to better inform producers and facilitate their decision-making and prepare the dairy industry to take another evolutionary step forward.
View Article and Find Full Text PDFHeat abatement (e.g., soakers, fans) effectively reduces the negative physiological and production effects of heat stress, but no previous studies have documented effective interventions for the reduced lying times observed in response to hot weather.
View Article and Find Full Text PDFThe objective of this preliminary observational study was to determine milking time behavior of cows in a free-flow automated (robotic) milking system (AMS) and identify potential factors that influenced the time waiting to be milked. Milking time behavior of 40 cows from 1 pen on a commercial dairy farm with a free-flow AMS was evaluated using video analysis over 2 d. For each study cow, data were assessed for waiting time to access the milking robot, the use of the fetch pen, robot refusals, and their lying behavior.
View Article and Find Full Text PDFCharacterizing the chemical state and physical disposition of uranium that has persisted over geologic time scales is key for modeling the long-term geologic sequestration of nuclear waste, accurate uranium-lead dating, and the use of uranium isotopes as paleo redox proxies. X-ray absorption spectroscopy coupled with molecular dynamics modeling demonstrated that pentavalent uranium is incorporated in the structure of 1.6 billion year old hematite (α-FeO), attesting to the robustness of Fe oxides as waste forms and revealing the reason for the great success in using hematite for petrogenic dating.
View Article and Find Full Text PDFIntroduction: This patient preference study sought to quantify the preferences of people living with COPD regarding symptom improvement in the UK, USA, France, Australia and Japan.
Methods: The inclusion criteria were people living with COPD aged 40 years or older who experienced ≥1 exacerbation in the previous year with daily symptoms of cough and excess mucus production. The study design included: 1) development of an attributes and levels grid through qualitative patient interviews; and 2) implementation of the main online quantitative survey, which included a discrete choice experiment (DCE) to allow assessment of attributes and levels using hypothetical health state profiles.
Standard methods for detection of hepatitis A virus and norovirus in at-risk foodstuffs are available, but currently there is no standard method for detection of hepatitis E virus (HEV) in pork products or other foods that can be contaminated with the virus. Detection assays for HEV are mainly based on nucleic acid amplification, particularly the reverse transcription polymerase chain reaction (RTPCR) in real-time format. RTPCR-based methods can be sensitive and specific, but they require a suite of controls to verify that they have performed correctly.
View Article and Find Full Text PDFMicroorganisms
December 2021
To progress towards a full comprehension of the risk caused by pathogenic microorganisms transmitted via food and environmental routes, extensive information on the prevalence, the mechanisms of contamination, and the survival of pathogens is required, particularly to assist with the development of effective systems to reduce contamination, and to formulate procedural control measures, such as the implementation of food safety criteria [...
View Article and Find Full Text PDFHealth technology assessment (HTA) agencies vary in their use of quantitative patient preference data (PP) and the extent to which they have formalized this use in their guidelines. Based on the authors' knowledge of the literature, we identified six different PP "use cases" that integrate PP into HTA in five different ways: through endpoint selection, clinical benefit rating, predicting uptake, input into economic evaluation, and a means to weight all HTA criteria. Five types of insight are distinguished across the use cases: understanding what matters to patients, predicting patient choices, estimating the utility generated by treatment benefits, estimating the willingness to pay for treatment benefits, and informing distributional considerations.
View Article and Find Full Text PDFBackground: Patient preference information is increasingly being used to inform decision making; however, further work is required to support the collection of preference information in rare diseases. This study illustrates the use of direct preference elicitation methods to collect preference data from small samples in the context of early decision making to inform the development of a product for the treatment of immunoglobulin A nephropathy.
Method: An interview-based swing weighting approach was used to elicit preferences from 40 patients in the US and China.
Int J Technol Assess Health Care
April 2021
Objectives: To develop an international template to support patient submissions in Health Technology Assessments (HTAs). This was to be based on the experience and feedback from the implementation and use of the Scottish Medicines Consortium's (SMC) Summary Information for Patient Groups (SIP).
Methods: To gather feedback on the SMC experience, web-based surveys were conducted with pharmaceutical companies and patient groups familiar with the SMC SIP.
Understanding the movement of radionuclides (RNs) between different mineral hosts during processing of base metal ores is critical for accurate modelling of RN deportment and optimisation of processes designed to reduce or eliminate RNs. Here, we demonstrate that spatially resolving quantitative alpha particle autoradiography combined with backscatter electron imaging and energy dispersive X-ray spectroscopy (EDS) can establish the correlation between alpha-emitting RNs (notably Ra and Po, daughters of the abundant U decay series) and certain minerals, in different stages of processing. This is achieved by locating the RNs to a specific mineral grain, the species of which can subsequently be identified using EDS.
View Article and Find Full Text PDFIndividual feed consumption and animal weight were continuously recorded in grower pigs using an automated feeding system. Infrared images were recorded each time a pig entered the feeding system and infrared thermography provided radiated thermal measurements of the dorsal surface of each animal. Feed was withdrawn and the animals fasted for a period of 24 h three times during the growth of the animals at body weights of approximately 35, 65 and 105 kg.
View Article and Find Full Text PDFKnowledge of the behavior of technologically enhanced naturally occurring radioactive materials derived through the decay of U and its daughter products, and their subsequent fractionation, mobilization and retention, is essential to develop effective mitigation strategies and long-term radiological risk prediction. In the present study, multiple state-of-the-art, spatially resolved micro-analytical characterization techniques were combined to systematically track the liberation and migration of radionuclides (RN) from U-bearing phases in an Olympic Dam Cu flotation concentrate following sulfuric-acid-leach processing. The results highlighted the progressive dissolution of U-bearing minerals (mainly uraninite) leading to the release, disequilibrium and ultimately upgrade of daughter RN from the parent U.
View Article and Find Full Text PDFIntroduction: Pigmented villonodular synovitis (PVNS), also known as giant-cell tumour of the tendon sheath (GCTT), is a rare, benign proliferative tumour affecting the inner lining of synovial joints and tendon sheets. Information on treatment needs of PVNS patients to inform drug development is currently scarce. We conducted an exploratory qualitative study with PVNS patients to generate insights into the objective and emotional aspects related to their medical journey and experiences of living with this disease.
View Article and Find Full Text PDFBackground & Aims: There is currently no data on physician preferences regarding future therapies for non-alcoholic steatohepatitis (NASH); this study explores these preferences and characteristics that are relevant to physician decision-making when choosing a potential therapy for a patient with NASH. The results were compared with those from a similar patient preference survey which was conducted in parallel.
Method: Initial exploratory 30-minute telephone interviews were conducted to inform the design of a 15-minute quantitative online specialist physicians survey, containing direct questions and a preference survey.
Background/aims: Understanding patients' perspectives of their disease can inform drug development and treatment decisions. In this study, we compared the preferences and needs of patients with moderate and severe dry eye symptoms from four different countries.
Methods: A quantitative questionnaire was developed based on the self-explicated conjoint methodology and was administered to 160 patients with moderate or severe dry eye disease (DED) from Australia, Germany, UK and the USA.
BMJ Open Ophthalmol
December 2019
Objective: Dry eye disease is a multifactorial chronic disease, leading to ocular discomfort and visual disturbance with a substantial impact on quality of life. Therefore, the patient's perspective should be taken into account early in the drug development process. We have developed a step-by-step methodology based on the self-explicated conjoint approach to assess the needs and preferences of patients with moderate-to-severe dry eye disease.
View Article and Find Full Text PDFWe illustrate our experience of gathering patient insights on the most patient-relevant symptoms in chronic obstructive pulmonary disease (COPD) via a structured and systematic approach towards 'patient-centric' drug development, leveraging recent advances in digital technologies using online platforms. The four-step approach comprised the following: literature search, social media listening (SML) study, online bulletin board (OBB) exercise, and design of an online patient preference study (PPS). The initial online studies (SML and OBB) revealed that, besides dyspnoea and exacerbations, patients perceive cough and mucus production as equally important aspects of disease management for COPD.
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