Publications by authors named "Nier Zhong"
Article Synopsis
- Angiomotin-like 2 (AMOTL2) is decreased in the lungs of rats with pulmonary arterial hypertension (PAH), suggesting its potential role in the disease.
- Overexpression of AMOTL2 in these rats led to significant improvements, including reduced right ventricle pressure and hypertrophy, as well as decreased vessel wall thickness and collagen buildup.
- AMOTL2 appears to work by inhibiting the YAP1 signaling pathway, which is activated during hypoxia, indicating that targeting AMOTL2 could be a new treatment strategy for PAH.
Coronary heart disease is a cardiovascular disease with high morbidity and mortality. Although great progress has been made in treatment, the prognosis is still very poor. Therefore, this project aims to screen potential diagnostic markers and therapeutic targets related to the progression of coronary heart disease.
View Article and Find Full Text PDFOur initial studies detected elevated levels of 3,4-dihydroxyphenyllactic acid (DHPLA) in urine samples of patients with severe heart disease when compared with healthy subjects. Given the reported anti-inflammatory properties of DHPLA and related dihydroxylated phenolic acids (DPAs), we embarked on an exploratory multi-centre investigation in patients with no urinary tract infections to establish the possible pathophysiological significance and therapeutic implications of these findings. Chinese and Caucasian patients being treated for severe heart disease or those conditions associated with inflammation (WBC ≥ 10 ×10/L or hsCRP ≥ 3.
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- Atherosclerotic complications are notably more prevalent in people with diabetes due to hyperglycemia, which accelerates foam cell formation in macrophages.
- Researchers used a combination of LPS and IFN-γ to activate THP-1 macrophages in both high glucose and normal conditions, analyzing lipid accumulation, gene expression, and metabolic changes.
- Findings revealed that high glucose not only increases lipid accumulation and inflammation in macrophages but also alters metabolic pathways, leading to the buildup of harmful lipids that contribute to atherosclerosis.
piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure.
Aging (Albany NY)
March 2022
Purpose: Previous studies found that piRNAs could participate in disease progression by regulating DNA methylation, but there are few reports on their roles in heart failure (HF).
Methods: The level of piRNA-6426 in the venous blood of HF patients and volunteers was detected by RT-qPCR. Hypoxia-induced cardiomyocytes were transfected with lentiviral-mediated piRNA-6426 overexpression vector (LV-piRNA-6426) or together with LV-DNMT3B, and then cell viability and apoptosis, glucose uptake, ROS production, LDH activity and secretion of inflammatory factors were detected.
BACKGROUND This study observed the incidence of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) and discusses the risk factors of ISR based on clinical data, coronary angiography, and stent features, to provide a theoretical basis for the prevention and treatment of ISR. MATERIAL AND METHODS We selected 1132 cases who received stent implantation at the Shaanxi People's Hospital from June 2014 to June 2016 and were followed up by coronary angiography within 1 year. Based on coronary angiography, the cases were divided into ISR and non-ISR groups.
View Article and Find Full Text PDFReduced expression of HCN channels in the sinoatrial node of streptozotocin-induced diabetic rats.
Can J Physiol Pharmacol
May 2017
Diabetes mellitus (DM) is associated with an electrical remodeling of the heart, increasing the risk of arrhythmias. However, knowledge of electrical remodeling in the sinoatrial node (SAN) by DM is limited. We investigated the expression of HCN channel isoforms, HCN1-HCN4, in SAN from streptozotocin (STZ)-induced diabetic rats and the age-matched controls.
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