Clinical and radiological predictors for persistent complaints five years after a lateral ankle sprain: A long-term follow-up study in primary care.

Objectives: To examine the five-year prognosis and potential prognostic factors of patients with an acute lateral ankle sprain in primary care setting.

Design: Observational study.

Methods: 206 patients who participated in a cross-sectional study and visited their general practitioner with an acute lateral ankle sprain 6-12 months prior to inclusion were approached for a 5-year follow-up measurement consisting of an online questionnaire.

Magnetic resonance imaging abnormalities after lateral ankle trauma in injured and contralateral ankles.

Purpose: To compare the prevalence of abnormal MRI findings associated with lateral ankle trauma in injured and contralateral ankles to identify lesions that may be pre-existent.

Material And Methods: The study was approved by the institutional review board and informed consent was obtained from all subjects. 195 patients (mean age 37.

Structural abnormalities and persistent complaints after an ankle sprain are not associated: an observational case control study in primary care.

Background: Persistent complaints are very common after a lateral ankle sprain.

Aim: To investigate possible associations between structural abnormalities on radiography and MRI, and persistent complaints after a lateral ankle sprain.

Design And Setting: Observational case control study on primary care patients in general practice.

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life.

Studies of reduced neonatal lung function and wheezing illnesses during childhood show conflicting results. The aim of our study was to assess the association between resistance (Rrs) and compliance (Crs) of the respiratory system by using the single occlusion technique (SOT) and prospectively collected wheezing illnesses during the first 5 years of life in a large birth cohort. SOT was performed during natural sleep before the age of 2 months.

Early life lung function and respiratory outcome in the first year of life.

Abnormal early life lung function is related to wheezing in childhood; however, data on the association with cough are not available. We determined the relationship between early life lung function and wheeze and cough during the first year of life, adjusted for other possible risk factors. Infants were participants of the Wheezing Illnesses Study Leidsche Rijn (WHISTLER).

Respiratory symptoms in young infancy: child, parent and physician related determinants of drug prescription in primary care.

Purpose: Respiratory symptoms account for the majority of drug prescriptions in the first year of life. We investigated the influence of child, parent and physician factors on drug prescriptions for respiratory symptoms in primary care in infancy.

Methods: Infants participated in the WHeezing Illnesses STudy LEidsche Rijn (WHISTLER), a prospective birth cohort on respiratory illnesses.

Early cardiac abnormalities in obese children: importance of obesity per se versus associated cardiovascular risk factors.

We investigated whether obese children and adolescents have early echocardiographic signs of subclinical cardiac dysfunction and evaluated the respective influence of obesity per se versus parameters of carbohydrate and lipid metabolism that are frequently abnormal in obese subjects. The role of tissue Doppler imaging as a screening tool for these abnormalities was explored. Blood pressure and echocardiographic parameters, including tissue Doppler measurements of the septal mitral annulus were evaluated in 49 obese children and adolescents and 45 age and sex matched controls.

The influence of maternal respiratory infections during pregnancy on infant lung function.

Introduction: We studied whether maternal respiratory infections during pregnancy adversely influence lung growth and development of the offspring, resulting in poor early life lung function.

Methods: Infants were participants of the Wheezing Illnesses Study Leidsche Rijn (WHISTLER). Lung function measurements (single occlusion technique) were performed during natural sleep.

Determinants of health care utilization for respiratory symptoms in the first year of life.

Objective: Health care utilization for respiratory symptoms is very common in infancy. Little is known about the determinants of visiting a physician for such complaints in infants. We investigated which factors determine the likelihood of visiting a physician for respiratory symptoms in the first year of life of their offspring.

Tobacco smoke exposure of pregnant mothers and blood pressure in their newborns: results from the wheezing illnesses study Leidsche Rijn birth cohort.

There is evidence to suggest that exposure of pregnant women to tobacco smoke is related to higher childhood blood pressure in their offspring. It is not well known whether this association is set in utero or by shared postnatal environments. The objective of this study was to assess the association between tobacco smoke exposure of pregnant mothers and blood pressure and heart rate of their newborns.