Publications by authors named "Nienke Wolfhagen"
Article Synopsis
- - The study examined the real-world effects of stereotactic body radiotherapy (SBRT) in patients with stage I non-small cell lung cancer (NSCLC), focusing on acute toxicity and 90-day mortality rates among 7,279 patients treated between 2017 and 2021.
- - Acute toxicity occurred in 3.8% of patients, while 90-day mortality was at 1.7%, with certain factors like age, sex, and lung function impacting these outcomes.
- - The findings suggest that SBRT has a low rate of acute toxicity and acceptable mortality, with developed prediction models aiding in identifying patients at higher risk for adverse effects.
In transplantation, hypothermic machine perfusion (HMP) has been shown to be superior to static cold storage (SCS) in terms of functional outcomes. Ex vivo machine perfusion offers the possibility to deliver drugs or other active substances, such as Mesenchymal Stem Cells (MSCs), directly into an organ without affecting the recipient. MSCs are multipotent, self-renewing cells with tissue-repair capacities, and their application to ameliorate ischemia- reperfusion injury (IRI) is being investigated in several preclinical and clinical studies.
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- Surgical resection is a common treatment for recurrent pulmonary metastases in colorectal cancer, but research on repeat surgeries is limited, prompting this study to analyze outcomes from a large audit in the Netherlands.
- Out of 1,237 patients analyzed, those undergoing repeat metastasectomy had a 5-year overall survival rate similar to those who had their first surgery (53% vs 52%), but faced more complications post-surgery.
- Key factors affecting survival included overall health status, number of metastases, and lung function, indicating the complexity of managing surgical options for these patients.
Background: The COVID-19 pandemic caused disruption of regular healthcare leading to reduced hospital attendances, repurposing of surgical facilities, and cancellation of cancer screening programmes. This study aimed to determine the impact of COVID-19 on surgical care in the Netherlands.
Methods: A nationwide study was conducted in collaboration with the Dutch Institute for Clinical Auditing.
Background: Hypothermic machine perfusion (HMP) is a well-established method for deceased donor kidney preservation. Normothermic machine perfusion (NMP) might offer similar or greater advantages. We compared the 2 methods in an ex vivo perfusion model using 34 porcine kidneys.
View Article and Find Full Text PDFBackground: Sustained ventricular tachycardia (susVT) and ventricular fibrillation (VF) are observed in adult patients with congenital heart disease (CHD). These dysrhythmias may be preceded by non-sustained ventricular tachycardia (NSVT). The aims of this study are to examine the 1] time course of ventricular tachyarrhythmia (VTA) in a large cohort of patients with various CHDs and 2] the development of susVT/VF after NSVT.
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