Age-Related Cognitive and Volumetric Changes in the Brain of African Grasscutter ( (Temminck, 1827)).

The African grasscutter (AGC) () is the second largest rodent in sub-Saharan Africa. It is bred for its organoleptic and culinary properties but also serves as a research model. The aim of this study was to investigate the relationship between age-related changes in brain weight, brain volume, and spatial and nonspatial memory performance in the AGC.

Reduced mitochondrial size in hippocampus and psychiatric behavioral changes in the mutant mice with homologous mutation of .

Background: Deafness-dystonia-optic neuronopathy (DDON) syndrome, a condition that predominantly affects males, is caused by mutations in () () gene and characterized by progressive deafness coupled with other neurological abnormalities. In a previous study, we demonstrated the phenotype of male mice carrying the hemizygous mutation of . In a follow-up to that study, this study aimed to observe the behavioral changes in the female mutant (MUT) mice with homologous mutation of and to elucidate the underlying mechanism for the behavioral changes.

Frameshift mutation of gene in mouse leads to an abnormal mitochondrial structure in the brain, correlating with hearing and memory impairment.

Background: Deafness-dystonia-optic neuronopathy (DDON) syndrome is a progressive X-linked recessive disorder characterised by deafness, dystonia, ataxia and reduced visual acuity. The causative gene deafness/dystonia protein 1 ()translocase of the inner membrane 8A () encodes a mitochondrial intermembrane space chaperon. The molecular mechanism of DDON remains unclear, and detailed information on animal models has not been reported yet.