Changes in facial morphology in Macaca mulatta: a cephalometric study from 1.5 to 5 years of age.

A cross-sectional and longitudinal (3.5 years) study on the craniofacial growth of 10 male rhesus monkeys, using metallic implants and a radiographic cephalometric technique based mainly on angular measurements, led to the following observations. (1) Maxilla and mandible were displaced in a forward and downward direction during growth, the sagittal changes being predominant over the vertical changes.

Maxillary superimposition: a comparison of three methods for cephalometric evaluation of growth and treatment change.

Two anatomic methods are statistically compared with the implant method for superimposing serial head films in 18 subjects with metallic implants. Findings showed that the "best fit" method--that is, superimposition along the palatal plane registered at ANS--traditionally used by orthodontists, significantly underestimates the eruption of the teeth by 30% to 50%. The "structural method," which is based on the use of stable structures in the maxilla, showed no significant differences in vertical displacement of selected landmarks in comparison with the implant method.

[Generalized argyria due to the use of eyedrops containing silver nitrate].

This paper describes a case of generalized argyria secondary to the excessive use of eye-drops containing silver nitrate. The diagnosis was confirmed by a skin biopsy showing deposits of metallic silver in the dermis.

Hemoglobinopathies in Danish families.

Based on cases referred for investigation, as well as a questionnaire sent to all medical and pediatric departments in Denmark, 48 cases of hemoglobinopathy in 15 families of Danish ancestry are reviewed. 18 Danes in six families have been identified as having beta-thalassemia, and remarkably one - a homozygote - has beta-thalassemia intermedia requiring treatment with iron-chelation therapy. A further 36 Danes in 9 families have a hemoglobin variant: five unstable hemoglobins (Volga, Niteroi, and three unidentified), one hereditary methemoglobinemia (M-Arhus), one polycythemia (Ty Gard) and 2 asymptomatic (Athens-Georgia and Hafnia).

Fatal familial cholestatic syndrome in Greenland Eskimo children. A histomorphological analysis of 16 cases.

We report the first detailed study of hepatic morphology in 28 biopsies from 16 Greenland Eskimo children with fatal familial cholestatic syndrome. The changes were categorized as early, intermediate and late. In the early stage, until 5 months of age, changes were restricted to zone 3, consisting of cholestasis and rosette formation without fibrosis.

Secondary lens implantation.

A retrospective study is presented of a series of anterior chamber lens implantation in 64 eyes of 54 patients after an earlier cataract extraction. Best corrected final post-operative visual acuity was better or the same of best corrected pre-operative vision in 93.8% of eyes.

Adverse reaction to procaine penicillin G in horses.

Adverse reactions to intramuscular injections of procaine penicillin G are reported in 11 horses, five of which died. The clinical findings are presented and suggest central nervous involvement in most cases. Post mortem findings in one horse were consistent with anaphylaxis whereas in other cases the clinical findings, duration of treatment, speed of onset and subsequent completion of treatment supports diagnosis of an acute procaine toxicity syndrome.

Derivatives of 2-methylenepropane-1,3-diol as new antagonists of platelet activating factor.

Two new achiral platelet activating factor (PAF) antagonists, N-[5-[[2-methylene-3- [[(octadecylamino)carbonyl]oxy]propoxy]carbonyl]pentyl]pyridinium bromide and 3-[6-[[2-methylene-3- [[(octadecylamino)carbonyl]oxy]propoxy]carbonyl]hexyl]thiazolium bromide were synthesized from 2-methylenepropane-1,3-diol. Platelet aggregation in platelet-rich plasma from rabbits, induced by racemic C16-PAF, was competitively antagonized by 9 or 10. At concentrations less than or equal to 10(-4) M, neither compound 9 nor compound 10 caused platelet aggregation, nor did they inhibit platelet aggregation induced by collagen or adenosine diphosphate.

Random blood glucose sampling as an early antenatal screening test for diabetes mellitus.

Random blood glucose was measured on 1,992 pregnant women during the initial attendance at our antenatal clinic. The visit usually took place during the first part of the second trimester. Women with a random blood glucose concentration in excess of 6.

Response patterns of craniomandibular muscles with and without alterations in sensory feedback.

1. Surface EMG recordings were made bilaterally from the anterior part of the temporal muscle, superficial masseter muscle, and the suprahyoid complex of muscles while tracking mandibular incisor movement in three planes. This was done in 20 normal subjects with 16 different responses.

Diagnosis of trichomoniasis. Comparison of conventional wet-mount examination with cytologic studies, cultures, and monoclonal antibody staining of direct specimens.

The accuracy of (1) conventional wet-mount examination, (2) Papanicolaou-stained gynecologic smears, (3) a direct slide test using fluorescein-conjugated monoclonal antibodies against Trichomonas vaginalis, and (4) two different culture media for the diagnosis of trichomoniasis in a high-risk population of 600 women was compared. Use of Feinberg-Whittington or Diamond's culture medium resulted in a diagnosis of 82 and 78 cases, respectively, and the combination of two cultures identified 88 infected women. In comparison, wet-mount examination detected only 53 (60%) of the cases.

Craniomandibular bone density in the primate as assessed by computed tomography.

Ten normal rhesus monkeys, five juvenile and five adult animals, were analyzed for symmetry in bone density across the cranioskeleton with computed tomography (CT). Fifty contiguous axial CT scans were done using 1.5-mm thick scans between the lower mandibular border and inferior orbital ridge, and 3-mm thick scans from the inferior orbital ridge to the rostral level of insertion of the temporalis muscle.

The fate of the split thickness skin graft in neovaginas. A pathologic study of 21 cases and a review of the literature.

Twenty-one cases of congenital absence of the vagina corrected by McIndoe's procedure were examined. The longest follow-up was 21 years (average 10.5 years).

Results following reduction mammaplasty as evaluated by the patients.

Reduction mammaplasty was performed on 365 patients using the technique of Pers and Bretteville-Jensen. Two to 13 years after the operation, the patients were asked to complete questionnaires; the answers were analyzed and compared with answers from a smaller group of patients who had undergone surgery with McKissock's technique. Primary complications to the procedure were few, and it is remarkable that total necrosis of the nipple was absent in the series.

Fatal familial cholestatic syndrome in Greenland Eskimo children.

A syndrome of intrahepatic cholestasis leading to death in early childhood was studied in 16 Greenland Eskimo children. The pedigrees are compatible with autosomal recessive inheritance. Jaundice, bleeding, pruritus, malnutrition, steatorrhoea, osteodystrophy and dwarfism were typical clinical features.