Publications by Niels Mikkel Dyrby Breum

Publications by authors named "Niels Mikkel Dyrby Breum"

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Semi-rational Engineering of a Promiscuous Fatty Acid Hydratase for Alteration of Regioselectivity.

Yan Zhang Niels Mikkel Dyrby Breum Sune Schubert Negin Hashemi Rikke Kyhnau

Chembiochem

February 2022

Fatty acid hydratases (FAHs) catalyze regio- and stereo-selective hydration of unsaturated fatty acids to produce hydroxy fatty acids. Fatty acid hydratase-1 (FA-HY1) from Lactobacillus Acidophilus is the most promiscuous and regiodiverse FAH identified so far. Here, we engineered binding site residues of FA-HY1 (S393, S395, S218 and P380) by semi-rational protein engineering to alter regioselectivity.

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