Publications by authors named "Niels M Frandsen"

Article Synopsis
  • - The miR-17-92 cluster is linked to cancer growth and serves as a target for treatment in MYC-driven cancers; researchers developed LNA gapmeR antisense oligonucleotides (ASOs) to stop the production of these oncogenic miRNAs.
  • - The key ASO, MIR17PTi, successfully inhibited the growth of multiple cancer cell lines and triggered cell death in multiple myeloma (MM) by disrupting critical regulatory loops involving MYC and miR-17-92.
  • - In animal studies, MIR17PTi showed strong anti-tumor effects and favorable safety, paving the way for potential early-phase clinical trials against MM and other cancers associated with MYC overexpression
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Locked nucleic acid (LNA) oligonucleotides have been successfully used to efficiently inhibit endogenous small noncoding RNAs in vitro and in vivo. We previously demonstrated that the direct miR-221 inhibition by the novel 13-mer LNA-i-miR-221 induces significant antimyeloma activity and upregulates canonical miR-221 targets in vitro and in vivo. To evaluate the LNA-i-miR-221 pharmacokinetics and pharmacodynamics, novel assays for oligonucleotides quantification in NOD.

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Background & Aim: The miR-221/222 cluster is upregulated in malignant plasma cells from multiple myeloma (MM) patients harboring the t(4;14) translocation. We previously reported that silencing of miR-221/222 by an antisense oligonucleotide induces anti-MM activity and upregulates canonical miR-221/222 targets. The in vivo anti-tumor activity occurred when miR-221/222 inhibitors were delivered directly into MM xenografts.

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MicroRNA-21 (miR-21) is thought to be an oncomir because it promotes cancer cell proliferation, migration, and survival. miR-21 is also expressed in normal cells, but its physiological role is poorly understood. Recently, it has been found that miR-21 expression is rapidly induced in rodent hepatocytes during liver regeneration after two-thirds partial hepatectomy (2/3 PH).

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Unlabelled: MicroRNAs (miRNAs) constitute a new class of regulators of gene expression. Among other actions, miRNAs have been shown to control cell proliferation in development and cancer. However, whether miRNAs regulate hepatocyte proliferation during liver regeneration is unknown.

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