Topical ciprofloxacin is superior to topical saline and systemic antibiotics in the treatment of tympanostomy tube otorrhea in children: the results of a randomized clinical trial.

Objectives/hypothesis: To compare the clinical failure rates among children with otorrhea through tympanostomy tubes treated with topical or systemic antibiotics versus topical saline.

Study Design: Randomized, double-blind, controlled patient study.

Methods: A three-armed randomized clinical trial using topical ciprofloxacin or oral amoxicillin or topical saline.