Publications by authors named "Niels Christian Lory"
Article Synopsis
- Drug-based antiretroviral therapies (ART) effectively control HIV replication but can't eliminate the virus since it remains as integrated proviral reservoirs in cells.
- Genome editing tools like the HIV-1 LTR-specific designer-recombinase Brec1 show promise in removing these integrated HIV genomes, indicating potential for curative therapies.
- A comprehensive preclinical study of Brec1 demonstrated it has minimal safety risks, including no harmful immune responses, making it a suitable candidate for future clinical trials aimed at eradicating HIV-1.
Article Synopsis
- * The study found that when these channels are absent, the formation of localized Ca signaling areas is impaired, affecting the speed and efficiency of T cell activation and their subsequent responses, like cytokine production and proliferation.
- * Overall, purinergic signaling through P2X4 and P2X7 is essential for effective CD8 T cell function, highlighting the potential for targeting these pathways in future therapeutic strategies.
The transcription factor Interferon Regulatory Factor 4 (IRF4) is central in control of T cell activation and differentiation. Deficiency of IRF4 results in severe immune deficiency and affects maturation and function of most if not all T cell subsets. Here we use mouse infection models for and to analyze the function of IRF4 in T helper (Th) 17 and Th2 cell responses, respectively.
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- * Researchers created mice with active IL-6R in T cells to study its effects, finding that it led to lung inflammation and activated T cell accumulation, particularly TH17 cells.
- * While gp130 signaling in T cells promotes activated T cell presence and memory formation, it does not directly cause TH17 differentiation or lead to T cell lymphoma.
Article Synopsis
- * In liver infections from mice, the absence of these monocytes showed opposite effects; they reduced liver injury in parasitic infections but worsened conditions in listeria infections.
- * Analysis demonstrated different gene expression profiles, with parasite-infected monocytes exhibiting a more naive state while listeria-infected monocytes displayed a clear proinflammatory phenotype, suggesting the potential to categorize them into distinct subpopulations using specific markers.