Publications by authors named "Niels Aw Lemmermann"
Article Synopsis
- Cytomegaloviruses (CMVs), particularly murine CMV (MCMV), manipulate the immune system, specifically targeting the type I interferon (IFN) response through the protein m152.
- M152 binds to the stimulator of interferon genes (STING), delaying its movement to the Golgi, which is essential for activating the antiviral IFN signaling.
- While m152 inhibits STING's ability to trigger IFN-related responses, it does not impact its role in activating NF-κB signaling, allowing MCMV to benefit from early viral replication while counteracting the host's antiviral defenses.
