Publications by authors named "Niedt G"
Background: Cutaneous syncytial myoepithelioma (CSM) is an uncommon and distinct variant of cutaneous myoepithelioma. We aim to present a case of CSM to enhance the recognition of this unique variant, encompassing its clinical characteristics, histopathological features, immunohistochemical staining, and therapeutic approaches.
Case Presentation: A 10-year-old girl presented with a dome-shaped nodule located on the skin of her left medial distal arm.
Article Synopsis
- - Atypical fibroxanthoma (AFX) is a rare, low-grade skin tumor characterized by unusual features, including the presence of osteoclast-like giant cells, with fewer than 20 documented cases.
- - A 77-year-old man with a history of skin cancers presented with a growing scalp nodule; biopsy revealed AFX with giant cells and specific immunohistochemical markers.
- - Despite concerning histological features, AFX typically has a good prognosis, with low recurrence rates and very rare instances of metastasis, underlining the importance of proper diagnosis from other skin lesions.
Bortezomib-Induced Reticular Eruption in Patient with Multiple Myeloma.
Dermatopathology (Basel)
July 2023
Bortezomib is the first proteasome inhibitor to treat a variety of malignancies and is currently part of the standard of care regimen for the initial treatment of patients with newly diagnosed multiple myeloma. While bortezomib is generally well tolerated, it has been associated with various side effects, which have limited its use in some patients. Here, we describe a unique case with histological confirmation of a reticular eruption that appeared at the site of a subcutaneous administration of bortezomib in a 62-year-old male who was newly diagnosed with IgG kappa multiple myeloma.
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- * A case involving a 78-year-old patient revealed a skin rash following iodinated contrast administration, with significant symptoms noted soon after.
- * A biopsy performed within 24 hours showed specific histological features resembling cryptococcal infection, suggesting that early diagnosis of iododerma is possible.
Receptor for Advanced Glycated End-products (RAGE) is highly expressed in diabetes and impairs wound healing. We proposed that administering an antibody that blocks RAGE will hasten the healing of dorsal wounds in diabetic pigs compared with a non-immune IgG. Two purpose-bred diabetic (D) Yucatan minipigs (Sinclair, Auxvasse MO) each underwent 12 2 × 2 cm full thickness dorsal wounds: four wounds received decellularized porcine skin patches (Xylyx Bio, Bklyn NY): four anti-RAGE Ab (CR-3) infused patches, four saline infused patches and four wounds were left open.
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