Micronutrient Biofortification in Wheat: QTLs, Candidate Genes and Molecular Mechanism.

Micronutrient deficiency (hidden hunger) is one of the serious health problems globally, often due to diets dominated by staple foods. Genetic biofortification of a staple like wheat has surfaced as a promising, cost-efficient, and sustainable strategy. Significant genetic diversity exists in wheat and its wild relatives, but the nutritional profile in commercial wheat varieties has inadvertently declined over time, striving for better yield and disease resistance.

Treatment indications for antidepressants prescribed in primary health care facilities in Beijing, China.

To examine the prevalence of treatment indications for antidepressants and assessed temporal trends in antidepressant prescribing for depression among adult patients in primary health care facilities (PHFs) in China. Descriptive study of antidepressant prescriptions written by primary care physicians. Setting participants: Patients aged 18 years and above in 67 PHFs in Dongcheng district in Beijing between 1 January 2014 and 31 December 2022.

Antibiotic prescription in pediatric patients with influenza in outpatient and emergency departments: A cross-sectional study.

Background: Influenza is a common viral respiratory infection, and inappropriate antibiotic use may lead to increased drug resistance and unnecessary waste of healthcare resources. However, real-world antibiotic prescribing in pediatric influenza patients remains largely unknown in China.

Methods: We performed a cross-sectional study of outpatient and emergency department prescriptions in a tertiary children's hospital for pediatric patients diagnosed with influenza between January 1, 2021, and July 31, 2023.

Nociceptor Neurons Facilitate Orthodontic Tooth Movement via Piezo2 in Mice.

Multiple sensory afferents, including mechanosensitive and nociceptive nerves, are projected to the periodontium. Peptidergic afferents expressing transient receptor potential vanilloid 1 (TRPV1), a receptor for capsaicin, mediate pain caused by orthodontic forces. However, their role in orthodontic force-induced alveolar bone remodeling is poorly understood as is the contribution of mechanosensitive ion channels such as Piezo2 in nociceptive nerves.

Dynamic Chirality in Nature-Inspired Photonic Crystal Films: Ultralong Room Temperature Phosphorescence and Stimuli-Responsive Circularly Polarized Luminescence.

Circularly polarized luminescence (CPL) systems exhibiting room-temperature phosphorescence (RTP) are attracting considerable attention for applications in information encryption and smart sensing. However, achieving ultralong circularly polarized RTP (CPRTP) with tunable chirality and stimuli-responsive CPL remains challenging. Inspired by the color-changing properties of the butterfly, we developed a cellulose nanocrystal (CNC)-based photonic crystal film with an ultralong RTP lifetime of 2.

RBMS3-loss impedes TRIM21-induced ubiquitination of ANGPT2 in an RNA-independent manner and drives sorafenib resistance in hepatocellular carcinoma.

Sorafenib, a first-line targeted drug for advanced hepatocellular carcinoma (HCC), has limited clinical application due to intrinsic/acquired resistance. In this study, we have identified the RNA-binding protein RBMS3 as a pivotal regulator involved in sorafenib resistance among patients with HCC. Loss- and gain-of-function experiments further demonstrate that downregulation of RBMS3 promotes angiogenesis and confers resistance to sorafenib by augmenting the capacity of HCC cells to express and secrete ANGPT2, while upregulation of RBMS3 reverse these phenotypes.

Asiaticoside-nitric oxide synergistically accelerate diabetic wound healing by regulating key metabolites and SRC/STAT3 signaling.

Background: Diabetic wounds pose significant clinical challenges due to impaired healing processes, often resulting in chronic, nonhealing ulcers. Asiaticoside (AC), a natural triterpene derivative from , has demonstrated notable anti-inflammatory and wound-healing properties. However, the synergistic effects of nitric oxide (NO)-a recognized promoter of wound healing-combined with AC in treating diabetic wounds remain inadequately explored.

Cerebral Edema Progression and Outcomes in Large Infarct Patients Undergoing Endovascular Thrombectomy.

Objective: The goal was to analyze the progression of cerebral edema post-endovascular thrombectomy (EVT) in large infarcts and its association with functional outcomes.

Methods: A secondary analysis of the Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core trial was conducted in patients with large ischemic cores randomized to receive either EVT or medical management (MM) alone. Patients who had follow-up imaging within 7 days post-randomization were involved.

TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.

Tuberculosis results from Mycobacterium tuberculosis (Mtb) infection. Immune responses controlled by Toll-like receptor 4 (TLR4) are closely associated with the host response to pathogens, including Mtb. NLRP3 inflammasome-mediated pyroptosis forms a significant part of the inflammatory response during Mtb infection, and endoplasmic reticulum stress (ERS) is implicated in the activation of the NLRP3 inflammasome.

A novel four-species microbial consortium for nutritional value improvement of rapeseed meal.

This study explores the potential of artificial microbial consortia to enhance rapeseed meal nutritional value. A novel four-species microbial consortium consisting of Bacillus subtilis, Lactobacillus plantarum and two screened glucosinolates-degradation strains Erwinia tasmaniensis and Enterococcus gallinarum was constructed for nutritional value improvement in rapeseed meal. Results demonstrated significant reductions in the concentrations of glucosinolates (86.

From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders.

In recent 10 years, ferroptosis has become a hot research direction in the scientific research community as a new way of cell death. Iron toxicity accumulation and lipotoxicity are unique features. Several studies have found that ferroptosis is involved in the regulation of the hepatic microenvironment and various hepatic metabolisms, thereby mediating the progression of related liver diseases.

A bio-based Janus hydrogel from cellulose and lignin with bilayer structure and asymmetric adhesion for accurate and sensitive human motion monitoring.

Janus hydrogels for human motion monitoring are thriving due to their conductivity, flexibility, anisotropy and self-adhesion, etc. However, most of them face challenges such as complex processes, interlayer detachment, and surface contamination, which degrade their sensing accuracy and sensitivity. Hence, this study proposes a facile strategy using the cellulose and lignin as building blocks to construct a Janus hydrogel for accurate and sensitive sensing.

A Single-Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging.

Aging disrupts immune regulation, affecting tissue function and increasing vulnerability to various diseases. However, the effects of aging on immune cells within human testes are not well understood. In this study, we utilized single-cell RNA sequencing to profile immune cells from 33 human testis samples from individuals aged 21 to 69.

ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity.

Inflammation is a crucial element of immune responses, with pivotal roles in host defenses against pathogens. Comprehensive understanding of the molecular mechanisms underlying inflammation is imperative for developing effective strategies to combat infectious diseases. Here, we conducted a screening analysis and identified enkurin domain-containing protein 1 (ENKD1) as a promising regulator of inflammation.

Ultrafast Thermal Conduction of Phase Change Fiber Enabled by Sheath Confinement-Induced Ordered Orientation of Hydroxylated BNNs.

Phase change fibers (PCFs) are increasingly popular in thermal storage and release applications, such as temperature management. However, a simple but effective integration of thermal conductive materials into PCFs to deliver ultrafast thermal conduction remains a big challenge. Herein, a facile one-pot coaxial wet spinning strategy based on sheath-confinement-induced orientation arrangement of hydroxylated boron nitride nanosheets (BNNs-OH) is proposed to fabricate the high-performance PCFs.

A safety risk assessment method for TBM tunnel construction based on attribute interval identification theory.

Based on the identification and analysis of safety risks in TBM tunnel construction, we construct a comprehensive safety risk dynamic evaluation index system tailored to this context. To account for the dynamic nature of safety risks during TBM tunnel construction, variable weight theory is incorporated, allowing for a more accurate reflection of the time-varying importance of risk indicators. Building on the theoretical framework of attribute interval recognition theory, we establish a TBM tunnel construction safety risk evaluation model grounded in attribute interval theory.

Survival impact and risk factors of skeletal muscle loss during first-line EGFR-TKIs therapy in advanced lung adenocarcinoma patients.

Purpose: The impact of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) on muscle mass in individuals with advanced lung cancer has yet to be fully delineated. This study aimed to examine the dynamics of skeletal muscle mass during EGFR-TKIs targeted therapy, elucidate its clinical relevance, and explore the potential mechanisms.

Methods: We retrospectively recruited 104 patients with EGFR-mutant advanced lung adenocarcinoma who received icotinib or afatinib as first-line treatment.

Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness.

Psychological stress causes gut microbial dysbiosis and cancer progression, yet how gut microbiota determines psychological stress-induced tumor development remains unclear. Here we showed that psychological stress promotes breast tumor growth and cancer stemness, an outcome that depends on gut microbiota in germ-free and antibiotic-treated mice. Metagenomic and metabolomic analyses revealed that psychological stress markedly alters the composition and abundance of gut microbiota, especially Akkermansia muciniphila (A.

Single-cell transcriptomic atlas of the human testis across the reproductive lifespan.

Testicular aging is associated with declining reproductive health, but the molecular mechanisms are unclear. Here we generate a dataset of 214,369 single-cell transcriptomes from testicular cells of 35 individuals aged 21-69, offering a resource for studying testicular aging and physiology. Machine learning analysis reveals a stronger aging response in somatic cells compared to germ cells.

GWAS and eQTL analyses reveal genetic components influencing the key fiber yield trait lint percentage in upland cotton.

Lint percentage is an important component of cotton yield traits and an important economic indicator of cotton production. The initial stage of fiber development is a critical developmental period that affects the lint percentage trait, but the genetic regulation of the initial stage of fiber development needs to be resolved. In this study, we used a genomewide association study (GWAS) to identify 11 quantitative trait loci (QTLs) related to lint percentage and identified a total of 13 859 expression QTL (eQTLs) through transcriptome sequencing of 312 upland cotton accessions.

High-efficiency and high-brightness circular-clad, large-size, rectangular core crystalline waveguide Yb:YAG laser.

We report what we believe to be a novel circular-clad large-size rectangular core crystalline waveguide Yb:YAG laser. The waveguide has a rectangular core of Yb:YAG with 400 × 400 μm and a thin rod-shaped cladding of Er:YAG with a diameter of 1.2 mm and a length of 65 mm.

Environmentally relevant concentrations lithium exposure induces neurotoxicity in yellowstripe goby (Mugilogobius chulae): Responses of BDNF/AKT/FoxOs in regulating glutamate excitotoxicity and mitochondrial function.

The wide application of lithium in green energy and clinical psychiatry results in ubiquitous occurrence of lithium in aquatic environments. However, researches on the toxicity of lithium are largely confined to acute and/or high-dose scenarios, with insufficient data on its impacts on non-target organisms at environmental levels. The present study investigated the neurotoxicological effects of environmentally relevant concentrations of lithium exposure on yellowstripe goby (Mugilogobius chulae) and the related molecular response mechanisms.

GeM: Gaussian embeddings with Multi-hop graph transfer for next POI recommendation.

Next Point-of-Interest (POI) recommendation is crucial in location-based applications, analyzing user behavior patterns from historical trajectories. Existing studies usually use graph structures and attention mechanisms for sequential prediction with single fixed points. However, existing work based on the Markov chain hypothesis neglects dependencies of multi-hop transfers between POIs, which is a common pattern of user behaviors.

Clinical Severity and Outcomes in Large Infarcts With Endovascular Therapy: A Post Hoc Analysis of the ANGEL-ASPECT Trial.

Background: Endovascular therapy (EVT) has been proven effective for patients with acute ischemic stroke with large infarcts. This study aimed to explore the impact of clinical severity on the efficacy of EVT in such patients.

Methods: This was a post hoc analysis of the ANGEL-ASPECT trial (Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core), a randomized controlled trial that enrolled patients from 46 centers across China between October 2, 2020, and May 18, 2022.

Macromolecular and cytological changes in fission yeast G0 nuclei.

When starved of nitrogen, fission yeast Schizosaccharomyces pombe cells enter a quiescent "G0" state with smaller nuclei and transcriptional repression. The genomics of S. pombe G0 cells has been well studied, but much of its nuclear cell biology remains unknown.