ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner.

The N6-methyladenosine (m6A) modification serves as an essential epigenetic regulator in eukaryotic cells, playing a significant role in tumorigenesis and cancer progression. However, the detailed biological functions and underlying mechanisms of m6A regulation in gastric cancer (GC) are poorly understood. Our research revealed that the m6A demethylase ALKBH5 was markedly downregulated in GC tissues, which was associated with poor patient prognosis.

Molecular Beam Epitaxial Growth and Optical Properties of InN Nanostructures on Large Lattice-Mismatched Substrates.

Narrow-gap InN is a desirable candidate for near-infrared (NIR) optical communication applications. However, the absence of lattice-matched substrates impedes the fabrication of high-quality InN. In this paper, we employed Molecular Beam Epitaxy (MBE) to grow nanostructured InN with distinct growth mechanisms.

Analysis of Honing Material Removal Rate and Surface Quality Using Electroplated Oilstone.

The manufacturing precision of electro-hydraulic servo valve sleeves is critical to the performance and longevity of the valves. To ensure the service life of these valves, the valve sleeve is typically made from high-hardness martensitic stainless steel, which is considered a hard-to-cut material. Current honing methods often suffer from inefficiency and instability.

Research on the self-efficacy and resilience of female graduate students in the era of artificial intelligence: analysis of the mechanism of mobile phone dependence, anxiety and mentoring relationship.

Purpose: The purpose of this study is to investigate the impact of the employment situation on the anxiety levels and research self-efficacy of graduate students, with a particular focus on female graduate students. The study aims to understand how the use of AIGC tools, which has become more frequent among those with lower research self-efficacy, affects anxiety and research resilience. Additionally, the research explores the role of the mentoring relationship in influencing the psychological and academic experiences of female graduate students.

Boosting the Actuation Performance of a Dynamic Supramolecular Polyurethane-Urea Elastomer via Kinetic Control.

The ongoing soft actuation has accentuated the demand for dielectric elastomers (DEs) capable of large deformation to replace the traditional rigid mechanical apparatus. However, the low actuation strain of DEs considerably limits their practical applications. This work developed high-performance polyurethane-urea (PUU) elastomers featuring large actuation strains utilizing an approach of kinetic control over the microphase separation structure during the fabrication process.

Avian pathogenic alters complement gene expression in chicken erythrocytes.

1. Avian () causes significant losses in livestock by inducing morbidity and mortality. Erythrocytes, the most abundant in blood, possess dual functions of oxygen transportation and immune regulation.

Development and validation of a programmed cell death index to predict the prognosis and drug sensitivity of gastric cancer.

Aim: Programmed cell death (PCD) critically influences the tumor microenvironment (TME) and is intricately linked to tumor progression and patient prognosis. This study aimed to develop a novel prognostic indicator and marker of drug sensitivity in patients with gastric cancer (GC) based on PCD.

Methods: We analyzed genes associated with 14 distinct PCD patterns using bulk transcriptome data and clinical information from TCGA-STAD for model construction with univariate Cox regression and LASSO regression analyses.

Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer.

Background: Long noncoding RNAs (lncRNAs) play a critical role in gastric cancer (GC) progression and metastasis. However, research comprehensively exploring tissue-derived lncRNAs for predicting peritoneal recurrence in patients with GC remains limited. This study aims to investigate the transcriptional landscape of lncRNAs in GC with peritoneal metastasis (PM) and to develop an integrated lncRNA-based score to predict peritoneal recurrence in patients with GC after radical gastrectomy.

In-Situ Constructed Core-Shell Catalyst Enabling Subzero Capacity Unlocking of Cost-Effective and Long-Life Vanadium Flow Batteries.

Vanadium flow battery (VFB) promises a route for achieving grid-scale power storage by harnessing renewable energy sources. However, the sluggish reaction kinetics of vanadium redox couples and serious hydrogen evolution reaction (HER) still restrict the further development of VFB. Addressing these challenges requires not only effective solutions but also ones that are cost-efficient and scalable to meet the demands of affordable energy storage.

The complete mitochondrial genome of (Mannerheim, 1825) (Coleoptera: Chrysomelidae: Galerucinae): characterization and phylogenetic implications.

The leaf beetles have important economic and ecological significance. belongs to the subfamily Galerucinae. In this study, the complete mitogenome of has been obtained by the next-generation sequencing.

Food Functional Factors in Alzheimer's Disease Intervention: Current Research Progress.

Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disease. With the escalating aging of the global population, the societal burden of this disease is increasing. Although drugs are available for the treatment of AD, their efficacy is limited and there remains no effective cure.

GPR17 modulates anxiety-like behaviors basolateral amygdala to ventral hippocampal CA1 glutamatergic projection.

Anxiety disorders are one of the most epidemic and chronic psychiatric disorders. An incomplete understanding of anxiety pathophysiology has limited the development of highly effective drugs against these disorders. GPR17 has been shown to be involved in multiple sclerosis and some acute brain injury disorders.

Single-cell transcriptomic analysis reveals regulative mechanisms of follicular selection and atresia in chicken granulosa cells.

Eggs are an important food source for people. Follicle selection and atresia are the two directions of pre-hierarchical follicles that affect egg production in chickens. Granulosa cells (GCs), the vital somatic cells in follicles, determine the fate of follicles.

Solid-state synthesis of CN-encapsulated CoFe alloy catalysts for mild HMF oxidation to FDCA: insights into the kinetics and mechanism.

The efficient and environmentally friendly oxidation of biomass-based HMF to FDCA under mild conditions is highly desirable yet challenging. In this study, a series of CoFe alloy catalysts encapsulated in porous carbon (CoFe@NC) were synthesized using a solid-state synthesis method. By adjusting the Co/Fe ratio, an FDCA yield of 96.

The review of the genus (Coleoptera, Coccinellidae) from Pakistan.

Background: The genus is reviewed with seven species found in Pakistan: (Mulsant, 1866), Kapur, 1973, Dobzhansky, 1926, Fabricius, 1781, Linnaeus, 1758, Faldermann, 1835 and Linnaeus, 1758. Information on prey, host plants, distribution and an identification key for species in Pakistan is provided. Additionally, newly-sequenced partial COI (cytochrome-c-oxidase subunit I) for and were used to determine their phylogenetic positions within the genus .

Mineralizing Biofilm towards Sustainable Conversion of Plastic Wastes to Hydrogen.

The integration of inorganic materials with biological machinery to convert plastics into fuels offers a promising strategy to alleviate environmental pollution and energy crisis. Herein, we develop a type of hybrid living material via biomineralization of CdS onto Shewanella oneidensis-based biofilm, which is capable of sustainable hydrogen production from poly(lactic acid) (PLA) wastes under daylight. We reveal that the formed biofilm microstructure provides an independent anaerobic microenvironment that simultaneously supports cellular viability, maintains hydrogenase activity, and preserves the functional stability of CdS, giving rise to the efficient plastic-to-hydrogen conversion efficiency as high as 3751 μmol H g-1 PLA.

Phase transition induced hydrogen activation for enhanced furfural reductive amination over a CoCu bimetallic catalyst.

The synthesis of primary amines from renewable biomass and its derivatives through reductive amination has garnered significant attention. How to construct efficient non-noble-metal catalysts that enable low-temperature catalysis still remains challenging. Herein, we report a Cu-doped Co@CoO heterostructure catalyst that features structural Co-CoCuO bifunctional sites, which enable room temperature reductive amination of various aldehydes with 1.

Ground-based simulation of laser link acquisition for inter-satellite laser interferometry.

Laser link acquisition and pointing technique is one of the essential techniques for the inter-satellite laser interferometry for space-based gravitational waves detection and next-generation Earth gravity measurement missions. The first step of building up inter-satellite laser link is using an acquisition camera to capture the inter-satellite laser beam signals within a pre-scanning uncertain cone. Subsequently, high-precision angle measurement technology, namely differential wavefront sensing, is used to achieve a high pointing precision required.

Adaptive robust motion control for hydraulic load sensitive systems considering displacement dynamic compensation.

Hydraulic load-sensitive systems (HLSS) are widely used for high power density and energy efficiency. This study introduces an adaptive, energy-efficient HLSS with a valve-controlled variable motor. The system faces challenges from non-linearities, including internal higher-order dynamics due to displacement changes and external unknown disturbances, which hinder precision applications.

CAF-macrophage crosstalk in tumour microenvironments governs the response to immune checkpoint blockade in gastric cancer peritoneal metastases.

Background: Peritoneal metastasis is the most common metastasis pattern of gastric cancer. Patients with gastric cancer peritoneal metastasis (GCPM) have a poor prognosis and respond poorly to conventional treatments. Recently, immune checkpoint blockade (ICB) has demonstrated favourable efficacy in the treatment of GCPM.

Multi-omics profiling reveals the molecular mechanism of Bifidobacterium animalis BB04 in co-culture with Wickerhamomyces anomalus Y-5 to induce bifidocin A synthesis.

Bacteriocin is a kind of natural substance that can effectively inhibit bacteria, but its production usually limited by environment. Co-culture is a strategy to stimulate bacteriocin production. Bifidocin A produced by Bifidobacterium animalis BB04, is a novel bacteriocin with a broad-spectrum antimicrobial active of foodborne bacteria.