Publications by authors named "Nidhin Marimuthu"
In the study we have reported the physico-chemical, photophysical and morphological properties of chlorin e6 (Ce6) decorated doxorubicin (DOX) encapsulated chitosan (CS)-tripolyphosphate (TPP) nanoparticles which prepared by ionotropic gelation method. The Ce6 physically loaded onto the nanoparticles by self-assembly of CS with TPP-DOX under aqueous conditions. The results from DLS studies highlights the prepared nanoparticles that possess the size in the range of 80-120 nm.
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- The study investigates the use of silver nanoparticles (AgNPs) of different sizes (10nm, 35nm, 55nm) in creating a collagen-based scaffold for tissue engineering and wound healing.
- AgNPs were synthesized using pectin through a microwave method, and their incorporation improved the properties of collagen scaffolds, such as increased denaturation temperature and mechanical strength.
- Findings indicate that the 10nm Ag-pectin nanoparticles enhance both antibacterial activity and cell viability for keratinocytes, suggesting potential use in biomedical applications.
Native collagen is arranged in bundles of aligned fibrils to withstand in vivo mechanical loads. Reproducing such a process under in vitro conditions has not met with major success. Our approach has been to induce nanolinks, during the self-assembly process, leading to delayed rather than inhibited fibrillogenesis.
View Article and Find Full Text PDFCollagen-nanoparticle interactions are vital for many biomedical applications including drug delivery and tissue engineering applications. Iron oxide nanoparticles synthesized using starch template according to our earlier reported procedures were functionalized by treating them with Gum Arabic (GA), a biocompatible polysaccharide, so as to enhance the interaction between nanoparticle surfaces and collagen. Viscosity, circular dichroism (CD) and Fourier transform infrared spectroscopy (FTIR) techniques have been used to study the collagen-nanoparticle interactions.
View Article and Find Full Text PDFSynthesis of aligned hematite nanoparticles on chitosan-alginate films.
Colloids Surf B Biointerfaces
July 2009
Article Synopsis
- Iron oxide nanoparticles show potential in biomedical applications such as MRI enhancement, targeted drug delivery, and cancer cell separation.
- Templated synthesis using biocompatible polysaccharides like chitosan and alginate allows for the creation of nanoparticles with enhanced control over size and distribution while preventing aggregation.
- The produced nanoparticles are highly stable, superparamagnetic, and can be used directly or converted for further applications, enabling effective drug delivery to target sites.