Publications by authors named "Nidhi Parihar"
The surge in spinal cord injuries (SCI) attracted many neurobiologists to explore the underlying complex pathophysiology and to offer better therapeutic outcomes. The multimodal approaches to therapy in SCI have proven to be effective but to a limited extent. The clinical basics involve invasive procedures and limited therapeutic interventions, and most preclinical studies and formulations are yet to be translated due to numerous factors.
View Article and Find Full Text PDFAcne Vulgaris or Acne is a multifactorial bacterial infection caused by Propionibacterium acne, leading to inflammation and decreased quality of life, especially in adolescence. Currently, antibiotics and retinoids are preferred for treating acne. However, their continuous usage may lead to anti-microbial resistance and other side effects.
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- Delayed wound healing is primarily caused by bacterial infections and ongoing inflammation, necessitating materials with antibacterial, anti-inflammatory, and hemostatic properties for better recovery.
- This study introduces a new biomacromolecule-based scaffold (ArCh) made from a combination of arabinogalactan and chitosan, which is enhanced with Glycyrrhizin and Copper sulfide nanoparticles to improve wound healing effects.
- The results showed that these GACuS ArCh scaffolds excelled in swelling, biodegradation, and biocompatibility, and when subjected to NIR light, they exhibited improved hemostatic and antibacterial properties, indicating their potential in promoting faster tissue regeneration and healing.
Prolonged use of very commonly prescribed non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with undesired side effects, including gastrointestinal ulcers due to the non-selective inhibition of cyclooxygenases. We describe the development of an inflammatory-stimuli-responsive turn-on fluorogenic theranostic prodrug DCF-HS for adjuvant drug delivery. Upon activation by reactive oxygen species (ROS), the prodrug releases diclofenac DCF (active drug) and the NIR fluorophore DCI-NH2 along with carbonyl sulfide (COS).
View Article and Find Full Text PDFCoronavirus disease (COVID-19) is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) which was identified in Wuhan, China in December 2019 and jeopardized human lives. It spreads at an unprecedented rate worldwide, with serious and still-unfolding health conditions and economic ramifications. Based on the clinical investigations, the severity of COVID-19 appears to be highly variable, ranging from mild to severe infections including the death of an infected individual.
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- A new conjugate called LIC, combining lithocholic acid and IR 780 dye, is developed for treating and diagnosing triple-negative breast cancer.
- The LIC conjugate shows effectiveness as a photothermal and chemotherapeutic agent, improving tumor targeting and visualization in cancer therapy.
- Further enhancement through a polymeric nanosystem (LIPNCs) demonstrates better cellular uptake, significant heat generation under NIR light, and induces cancer cell death while being biocompatible, making it promising for future cancer treatment approaches.
Article Synopsis
- The novel β-coronavirus SARS-CoV-2 has presented a global health challenge, causing severe pneumonia and acute respiratory distress syndrome (ARDS), similar to past viral threats like HIV and influenza.
- A range of antiviral drugs, including phytochemicals, are under exploration to combat these viral infections, pointing toward potential future use as nutraceuticals.
- Herbal compounds (HC) exhibit antioxidant and antiviral properties and show promise in hindering COVID-19 viral replication, while also being recommended for further study as a functional food against various encapsulated viruses.
Parkinson's disease (PD) is a chronic motor disorder, characterized by progressive loss of dopaminergic neurons. Numerous studies suggest that glucagon-like peptide-1 (GLP-1) secretagogue has a neuroprotective role in PD models. The present study evaluated potential of coffee bioactive compounds in terms of their ability to bind GPR-40/43 and tested the neuroprotective effect of best candidate on rotenone-induced PD mice acting via GLP-1 release.
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