Process optimization and characterization of hydrolysate from underutilized brown macroalgae (Padina tetrastromatica) after fucoidan extraction through subcritical water hydrolysis.

The growing demand for macroalgal biomass as a source of proteins, peptides, and amino acids is garnering attention for their biological and functional properties. This study depicts the use of emerging green techniques, i.e.

Valorization of Kappaphycus alvarezii through extraction of high-value compounds employing green approaches and assessment of the therapeutic potential of κ-carrageenan.

This study utilizes different emerging green extraction technologies to recover maximum value-added products from Kappaphycus alvarezii and evaluate their bio-functional properties. Using the supercritical fluid extraction (SFE) method, the total lipid yield of 0.21 ± 0.

Deciphering the role of fucoidan from brown macroalgae in inhibiting SARS-CoV-2 by targeting its main protease and receptor binding domain: Invitro and insilico approach.

The current study investigated the role of fucoidan from Padina tetrastromatica and Turbinaria conoides against 3-chymotrypsin like protease (3CL) and receptor binding domain (RBD) spike protein of SARS-CoV-2 using an invitro and computational approach. The 3CL and RBD genes were successfully cloned in pET28a vector, expressed in BL-21DE3 E. coli rosetta cells and purified by ion exchange affinity and size exclusion chromatography.

Valorization of Wild-Type Cannabis indica by Supercritical CO2 Extraction and Insights into the Utilization of Raffinate Biomass.

Supercritical CO extraction (SCCO) extraction of cannabis oil from Indian cannabis () leaves was optimized through a central composite design using CO pressure (150-250 bar), temperature (30-50 °C) and time (1-2 h). From the regression model, the optimal CO pressure, extraction temperature and time were 250 bar, 43 °C and 1.7 h, respectively resulting in the experimental yield of 4.

Uncovering the phytochemicals of root exudates and extracts of lead (Pb) tolerant Chrysopogon zizanioides (L.) Roberty in response to lead contamination and their effect on the chemotactic behavior of rhizospheric bacteria.

The chemical composition of root exudates and root extracts from Chrysopogon zizanioides (L.) Roberty cv KS-1 was determined in the presence of lead [Pb(II)]. Hitherto, no information is available in the literature concerning the phytochemical components of root exudates of C.

Antiviral activity of sulfated polysaccharides from marine algae and its application in combating COVID-19: Mini review.

Marine-derived sulfated polysaccharides possess various antiviral activities against a broad range of enveloped and non-enveloped viruses. It has become the potential source of antiviral drugs for pharmaceutical development. In this review, we will discuss the different types of sulfated polysaccharides and their structural classification.

Antibody Combinations Targeting the Essential Antigens CyRPA, RH5, and MSP-119 Potently Neutralize Plasmodium falciparum Clinical Isolates From India and Africa.

Background: Targeting multiple key antigens that mediate distinct Plasmodium falciparum erythrocyte invasion pathways is an attractive approach for the development of blood-stage malaria vaccines. However, the challenge is to identify antigen cocktails that elicit potent strain-transcending parasite-neutralizing antibodies efficacious at low immunoglobulin G concentrations feasible to achieve through vaccination. Previous reports have screened inhibitory antibodies primarily against well adapted laboratory parasite clones.

Evaluation of the cytotoxicity and interaction of lead with lead resistant bacterium Acinetobacter junii Pb1.

This study explores the potential of lead resistant bacterium Acinetobacter junii Pb1 for adsorption/accumulation of lead using various techniques. In the present work, growth of A. junii Pb1 was investigated in the presence of a range of Pb(II) concentrations (0, 100, 250, 500, and 1000 mg l).

Improved methane yield from wastewater grown algal biomass.

Methane production from the algal biomass cultivated in a laboratory scale continuous photobioreactor (PBR) using sewage was evaluated in the present work. During the preliminary experiments, algal biomass reached up to 1.69 ± 0.

A critical review on speciation, mobilization and toxicity of lead in soil-microbe-plant system and bioremediation strategies.

Lead accumulation in soils is of serious concern in agricultural production due to the harmful effects on soil microflora, crop growth and food safety. In soil, speciation of lead greatly affects its bioavailability and thus its toxicity on plants and microbes. Many plants and bacteria have evolved to develop detoxification mechanisms to counter the toxic effect of lead.

Identification and localization of a Novel Invasin of Plasmodium falciparum.

Plasmodium falciparum is the causative organism for the most severe form of malaria among humans. The clinical symptoms are accredited to the asexual stage of parasite life cycle, involving merozoite invasion of erythrocyte, development and re-invasion into the new erythrocyte. Interaction of parasite proteins present on the surface or secreted from apical organelles with the host receptors is indispensable for the invasion process.

Identification and characterization of a novel Plasmodium falciparum adhesin involved in erythrocyte invasion.

Malaria remains a major health problem worldwide. All clinical symptoms of malaria are attributed to the asexual blood stages of the parasite life cycle. Proteins resident in apical organelles and present on the surface of P.

Effect of allopurinol on blood pressure: a systematic review and meta-analysis.

Allopurinol is a potent xanthine oxidase inhibitor that is used in hyperuricemic patients to prevent gout. It has also been shown to decrease cardiovascular complications in a myriad of cardiovascular conditions. However, studies have reported conflicting evidence on its effects on blood pressure (BP).

Identification of novel rhoptry neck protein of Plasmodium falciparum.

The clinical symptoms of malaria are attributed to the blood stage life cycle of parasite in which merozoite invades erythrocyte, undergoes multiplication and exit to re-invade into new erythrocyte to continue its life cycle. The interaction of repertoire of parasite proteins with host cell receptors is essential for invasion process. Identification, characterization and localization of the proteins involved in invasion will enrich our understanding of this complex process.

Takotsubo-like cardiomyopathy in pheochromocytoma.

Background: Takotsubo Cardiomyopathy (TTC) is commonly triggered by acute illness, physical or emotional stress and has been associated with elevated catecholamine levels. TTC has also been associated with pheochromocytoma (TTC-pheo).

Methods: We performed a computer assisted search of the electronic databases Medline, Scopus and Google Scholar from 1965 to January 2011.

Effects of mobile phone use on specific intensive care unit devices.

Background And Aims: To observe the effects of mobile phone use in the vicinity of medical devices used in a critical care setting.

Subjects And Methods: Electromagnetic interference (EMI) was tested by using two types of mobile phones - GSM and CDMA. Mobile phones were placed at a distance of one foot from three medical devices - syringe pump, mechanical ventilator, and the bedside monitor - in switch off, standby, and talking modes of the phone.