Turn-on detection of Al ions using quinoline-based tripodal probe: mechanistic investigation and live cell imaging applications.

In this study, an easily synthesizable Schiff base probe TQSB having a quinoline fluorophore is demonstrated as a fluorescent and colorimetric turn-on sensor for Al ions in a semi-aqueous medium (CHCN/water; 4 : 1; v/v). Absorption, emission and colorimetric studies clearly indicated that TQSB exhibited a high selectivity toward Al, as observed from its excellent binding constant ( = 3.8 × 10 M) and detection limit (7.

A quinoline derived Schiff base as highly selective 'turn-on' probe for fluorogenic recognition of Al ion.

A quinoline-derived Schiff base QnSb has been synthesized for fluorescent and colorimetric recognition of Al ions in a semi-aqueous medium. The compound QnSb has been characterized by elemental analysis, FT-IR, H/C NMR, UV-Vis and fluorescence spectral techniques. The crystal structure of the QnSb was confirmed by single crystal X-ray diffraction (SC-XRD) analysis.

In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma.

Background: Angiogenesis is an important hallmark of Glioblastoma (GBM) marked by elevated vascular endothelial growth factor-A (VEGF-A) and its receptor 2 (VEGFR-2). As previously reported nimbolide (NBL), trans-chalcone (TC) and piperine (PPR) possess promising antiangiogenic activity in several cancers however, their comparative efficacy and mechanism of antiangiogenic activity in GBM against VEGFR-2 has not been elucidated.

Methods: 2D and 3D spheroids cultures of U87 (Uppsala 87 Malignant Glioma) were used for evaluation of non-cytotxoic dose for anti-angiogenic activity.

Turn-on detection of Al and Zn ions by a NSN donor probe: reversibility, logic gates and DFT calculations.

An efficient dual functional naphthalene-derived Schiff base NpSb probe has been synthesised and evaluated for its fluorescence and chromogenic response towards metal ions. The NpSb probe was capable of selectively recognising Al and Zn ions when they were excited at the same wavelength in an aqueous organic solvent system. Almost non-fluorescent NpSb displayed a 'turn-on' fluorescence response when treated with Zn ( = 416 nm) and Al ( = 469 nm) ions due to the chelation-enhanced fluorescence (CHEF) effect.

Fluorescent and chromogenic organic probes to detect group 10 metal ions: design strategies and sensing applications.

Group 10 metals including Ni, Pd and Pt have been extensively applied in various essential aspects of human social life, material science, industrial manufactures, medicines and biology. The ionic forms of these metals are involved in several biologically important processes due to their strong binding capability towards different biomolecules. However, the mishandling or overuse of such metals has been linked to serious contamination of our ecological system, more specifically in soil and water bodies with acute consequences.

Targeting neuroblastoma by small-molecule inhibitors of human ALYREF protein: mechanistic insights using molecular dynamics simulations.

Neuroblastoma is a tumour of the sympathetic nervous system mainly prevalent in children. Many strategies have been employed to target several drug-targetable proteins for the clinical management of neuroblastoma. However, the heterogeneous nature of neuroblastoma presents serious challenges in drug development for its treatment.

Intranasal (2R, 6R)-hydroxynorketamine for acute pain: Behavioural and neurophysiological safety analysis in mice.

Ketamine is known for its antinociceptive effect and is also used for treatment-resistant depression. However, the efficacy and safety of (2R, 6R)-hydroxynorketamine (HNK), a ketamine metabolite has been sparingly investigated for acute pain management. The current study aims at investigating the antinociceptive effect of intranasal (2R, 6R)-HNK using pre-clinical models of acute pain.

Serum biomarkers based neurotrauma severity scale: a study in the mice model of fluid percussion injury.

The study aimed to investigate the significance of serum biomarkers in the severity grading of traumatic brain injury (TBI). For this purpose, mice underwent fluid percussion injury (FPI) at three discrete severity levels, mild, moderate, and severe. The severity of trauma was verified by the qualitative and quantitative histopathology of the brain.

& evaluations of PLGA nanoparticle based combinatorial drug therapy for baclofen and lamotrigine for neuropathic pain management.

Aim: Baclofen and Lamotrigine via PLGA nanoparticles were developed for nose-to-brain delivery for the treatment of Neuropathic pain.

Methods: Nanoparticles were prepared using the modified nano-precipitation method. The prepared NPs were characterised and further and studies were performed.

Intranasal Ketamine for Acute Pain: Behavioral and Neurophysiological Safety Analysis in Mice.

Background: Subanesthetic ketamine has been used for treatment-resistant depression and is popular as an opioid-sparing agent.

Objective: The present study aimed to investigate the dose-dependent antinociceptive effect of intranasal ketamine (INK) along with behavioral and neurophysiological safety in mice.

Methods: Antinociceptive efficacy was evaluated in the terms of thermal nociceptive response and formalin test.

A rare case of acute abdomen: spontaneous rupture of degenerated fibroid.

A 29-year-old nulliparous woman presented with an acute abdomen. She had a large uterus with multiple fibroids and was on the waiting list for elective surgery. An urgent CT scan demonstrated an extensive intraperitoneal fluid collection suspicious for fibroid rupture.

Clinical relevance of chronic neuropathic pain phenotypes in mice: A comprehensive behavioral analysis.

Despite a large number of preclinical studies performed each year, the safe and effective therapeutic interventions for chronic pain are scant. Therefore, it appears that pre-clinical modeling requires a systematically organized behavioral test paradigm to quantify the response of animals for a specific pain state. The present study, therefore, conceptualized a test battery to evaluate the behavioral changes in mice following neuropathic pain.

Low-pressure fluid percussion minimally adds to the sham craniectomy-induced neurobehavioral changes: Implication for experimental traumatic brain injury model.

Modeling experimental traumatic brain injury (TBI) in rodents is necessarily required to understand the pathophysiological and neurobehavioral consequences of neurotrauma. Numerous models have been developed to study experimental TBI. Fluid percussion injury (FPI) is the most extensively used model to represent clinical phenotypes.

Fluoride contamination in drinking water in rural habitations of northern Rajasthan, India.

This study was carried out to assess the fluoride concentration in groundwater in some villages of northern Rajasthan, India, where groundwater is the main source of drinking water. Water samples collected form deep aquifer based hand-pumps were analysed for fluoride content. Fluoride in presently studied sites was recorded in the ranges of 4.