Publications by authors named "Nida Sarosh Ashraf"
Peritoneal carcinomatosis represents an advanced stage of tumors within the peritoneal cavity. Once considered an incurable terminal cancer metastasis, contemporary medicine is on the hunt for certain potentially curative options alongside the present day's palliative disease management. However, for most patients, peritoneal carcinomatosis continues to pose a fatal late-stage prognosis with a grim future outlook.
View Article and Find Full Text PDFLaryngeal carcinoma (LC) is reported to have a higher incidence rate among all types of head and neck cancers around the globe. Mechanisms resulting in the pathogenesis of LC are complicated due to involvement of invasion and metastasis and there is a need to understand this complicated multistep process. Numerous molecules including matrix metalloproteinases (MMPs) are involved in regulating metastatic mechanisms.
View Article and Find Full Text PDFThe present study aimed to figure out the potential role of exosomal microRNAs, and their targeted genes in HNC detection/diagnosis. In the present study, exosomes were extracted from the serum samples of 400 HNC patients and 400 healthy controls. Exosomes were characterized using TEM, NTA, TEM-immunogold labeling and ELISA.
View Article and Find Full Text PDFHematologic malignancies (HMs) are a collection of malignant transformations, originating from the cells in the bone marrow and lymphoid organs. HMs comprise three main types; leukemia, lymphoma, and multiple myeloma. Globally, HMS accounts for approximately 10% of newly diagnosed cancer.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated the link between the gene SNP (rs2536) and the risk of reproductive cancers, analyzing 700 tumor samples from breast, ovarian, and cervical cancers alongside control tissues.
- - Researchers utilized Tetra-ARMS PCR to screen for the rs2536 genotype and quantitative PCR to assess gene expression levels.
- - Results indicated a significantly higher frequency of the homozygous mutant genotype of rs2536 in breast, ovarian, and cervical cancers, along with a notable downregulation of gene expression in tumors, suggesting an association with increased cancer risk.
The current study was designed to evaluate the diagnostic significance of the exosomal miRNAs and and the gene in brain tumor patients versus controls. Exosomes were extracted from the serum samples of 400 brain tumor patients and 400 healthy controls. The exosomes were characterized by scanning electron microscopy, dynamic light scattering and ELISA.
View Article and Find Full Text PDFArticle Synopsis
- - Exosomes, which are tiny vesicles found in all body fluids, play important roles in cell communication, particularly through their cargo of proteins and miRNAs, which can influence disease development by deregulating protein production.
- - The study focuses on specific exosomal miRNAs associated with rheumatoid arthritis (RA) and examines their roles in disease pathogenesis, using a sample of 306 RA patients and matched controls to assess expression levels and oxidative stress.
- - Results showed that several miRNAs were significantly downregulated in RA patients, while markers of oxidative stress and histone deacetylation were elevated, indicating a negative relationship between these miRNAs and disease severity.