Publications by authors named "Nida Ghafoor"
Bacterial resistance towards antibiotics is a significant challenge for public health, and surface-enhanced Raman spectroscopy (SERS) has great potential to be a promising technique to provide detailed information about the effect of antibiotics against biofilms. SERS is employed to check the antibacterial potential of a lab synthesized drug ([bis(1,3-dipentyl-1-imidazol-2(3)-ylidene)silver(i)] bromide) against and to analyze various SERS spectral features of unexposed and exposed strains by observing biochemical changes in DNA, protein, lipid and carbohydrate contents induced by the lab synthesized imidazole derivative. Further, PCA and PLS-DA are employed to differentiate the SERS features.
View Article and Find Full Text PDFObjective: To use Raman Spectroscopy for qualitative and quantitative evaluation of pharmaceutical formulations of active pharmaceutical ingredient (API) of Cephalexin.
Significance: Raman Spectroscopy is a noninvasive, nondestructive, reliable and rapid detection technique used for various pharmaceutical drugs quantification. The present study explores the potential of Raman Spectroscopy for quantitative analysis of pharmaceutical drugs.
Article Synopsis
- Insulin stored above FDA recommended temperatures can degrade and lead to poor glycemic control in diabetics, potentially causing serious conditions like type-2 diabetes and neurodegenerative diseases.
- The study aims to use Surface-enhanced Raman spectroscopy (SERS) to analyze insulin protein degradation over time when stored at room temperature.
- Researchers found that SERS effectively detected structural changes in insulin even after just 2 hours at room temperature, confirmed by multivariate analytical techniques like PCA.