Publications by authors named "Nicolo Schifano"
Article Synopsis
- Glans necrosis is an extremely rare complication post-circumcision in adult males, with only a few cases documented.
- Two cases are presented involving a 19-year-old and a 26-year-old, both treated successfully with oral medications and without needing hospitalization.
- Factors like penile dorsal anaesthetic blocks and cautery techniques have been linked to this complication, but there's no clear agreement on the best management approach, as outcomes have generally been favorable despite varying treatments.
Article Synopsis
- Cell therapy (CT) is being researched as a potential treatment for male sexual dysfunction (MSD), prompting a systematic review to assess its effectiveness and formulate official guidelines for the European Society for Sexual Medicine.
- A comprehensive search of medical databases identified 19 relevant studies involving 421 male patients, focusing mainly on erectile dysfunction, with most studies being case series rather than robust randomized controlled trials.
- Results showed significant improvements in erectile function based on various scales, with positive changes documented in over 70% of studies; some research also indicated benefits for patients with Peyronie's disease, highlighting the need for further investigation and validation of CT in this area.
The Possible Role of Prescribing Medications, Including Central Nervous System Drugs, in Contributing to Male-Factor Infertility (MFI): Assessment of the Food and Drug Administration (FDA) Pharmacovigilance Database.
Brain Sci
November 2023
Article Synopsis
- A study investigated the relationship between various medications and male-factor infertility (MFI), identifying a range of drugs potentially linked to the condition through a thorough review of the FDA's adverse event reporting database.
- Out of 955 MFI reports analyzed, 408 were associated with 20 specific medications, with notable findings on finasteride, testosterone, and diethylstilbestrol showing significantly high reporting ratios.
- The research concluded that while many medications already suspected of contributing to MFI were confirmed, some hypothesized agents were not represented, suggesting a need for further investigation in pharmacovigilance.
Article Synopsis
- Surgery is often chosen for Peyronie's disease (PD) due to its potential effectiveness despite risks and variable outcomes; the study investigates factors affecting patients' willingness to undergo such surgery.
- Conducted in five European centers from 2016-2020, the study analyzed data from 343 patients regarding their age, treatment history, and severity of PD symptoms to determine their attitude toward surgery.
- Results showed that about 37% of patients were willing to consider surgery, with factors like younger age influencing this willingness, despite many experiencing significant issues such as erectile dysfunction and penetration difficulties.
Article Synopsis
- * The main findings indicated that 14.8% of patients suffered from unfavorable outcomes due to significant complications or low quality-of-life scores post-surgery, with most patients showing good satisfaction overall.
- * Logistic regression revealed that middle-aged men faced a higher risk of dissatisfaction after PPI compared to younger and older patients, while other factors like erectile dysfunction cause and surgical volume didn't significantly affect outcomes.
Introduction: Animal models are frequently used for translational research in Peyronie's disease (PD). However, due to lack of availability of guidelines, there is some heterogeneity in study design, data reporting, and outcome measures.
Aim: This European Society for Sexual Medicine consensus statement aims to provide guidance in utilization of animal models in PD research in a standardized and uniform fashion.
Introduction: Erectile dysfunction (ED) affects between 12.9% and 28.1% of men worldwide, presenting a strong aged-correlated prevalence.
View Article and Find Full Text PDFBackground: Holmium laser enucleation of the prostate (HoLEP) is considered a challenging procedure even for surgeons who have completed the learning curve.
Objectives: To assess outcomes and complications following HoLEP performed by a highly experienced surgeon.
Design, Setting, And Participants: This was a single-institution prospective study (NCT03583034) performed at a tertiary referral centre that included 243 consecutive patients with lower urinary tract symptoms (LUTS) due to benign prostatic enlargement (BPE) treated with HoLEP by a single experienced surgeon (>1600 cases).
Purpose: To describe our surgical technique and report the oncological outcomes and complication rates using a fascial-sparing radical inguinal lymphadenectomy (RILND) technique for penile cancer patients with cN+ disease in the inguinal lymph nodes.
Methods: Over a 10-year period, 660 fascial-sparing RILND procedures were performed in 421 patients across two specialist penile cancer centres. The technique used a subinguinal incision with an ellipse of skin excised over any palpable nodes.
Hyaluronic acid (HA) is a glycosaminoglycan widely utilised in different fields of medicine. We aimed to provide a comprehensive overview of the scientific evidence on the use of HA in andrology. A review of the literature to identify pertinent studies concerning the use of HA in andrology was carried out on the Medline, EMBASE, and the Cochrane databases, with no time restriction up to December 2022.
View Article and Find Full Text PDFObjectives: To investigate which infertile men with semen parameters above WHO reference limits at first semen analysis deserve a second semen test.
Materials And Methods: Data from 1358 consecutive infertile men were analysed. Patients underwent two consecutive semen analyses at the same laboratory.
Background: Recurrent pregnancy loss and unexplained infertility are the current indications to test sperm DNA fragmentation according to the European Association of Urology Guidelines on sexual and reproductive health.
Objective: To identify a novel and better performing model to diagnose primary infertile men presenting with altered sperm DNA fragmentation and to outline its predictive ability in respect to current European Association of Urology Guidelines' recommendations.
Materials And Methods: Data from the latest 515 consecutive primary infertile men as for World Health Organization criteria were analyzed.
Context: The outcomes and morbidity following treatment for persistent or varicocele recurrence remain controversial.
Objective: To conduct a systematic review relating to the outcomes following treatment (any surgical or radiological) for varicocele persistence/recurrence.
Evidence Acquisition: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement.
Background: Peyronie's disease (PD) has a huge impact on patients' physical and psychological wellbeing.
Objectives: To investigate whether patients' age has an impact on PD symptomatic burden at first presentation.
Materials And Methods: Data from 129 consecutive heterosexual patients seeking first medical attention for PD at a single andrological tertiary-referral centre were collected.
Recreational drug intake may be associated with a range of medical untoward consequences, including male infertility. However, as the related evidence is still limited, the main outcome of this review is to provide a better understanding of the existence of any association between recreational drug misuse and male fertility levels' decline. Whilst searching the MEDLINE/PubMed, a comprehensive overview of the literature regarding male infertility and substances of abuse (e.
View Article and Find Full Text PDFPenile prosthesis implantation continues to represent a reliable solution to address erectile dysfunction when oral medications fail, are not tolerated or are contraindicated, and most typically is associated with excellent satisfaction rates and durable results. Despite the dramatic improvements in the prostheses' design, in the surgical instruments and techniques over the years, certain categories of patients still pose a significant surgical challenge. The aim of the current review is to provide a quick and useful practical guidance based on our expertise in the identification and management of the difficult penile prosthesis implantation cases.
View Article and Find Full Text PDFContext: The benefits and harms of varicocele treatment versus observation in adult infertile males are still controversial.
Objective: To systematically pool the evidence on outcomes of varicocele treatment (any surgical or radiological) versus observation in adult infertile men.
Evidence Acquisition: A systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement.
Background: Alfa-fetoprotein (AFP) is a serum glycoprotein highly produced during fetal development. While AFP synthesis drops dramatically after birth, AFP production only persists or returns under specific pathological condition.
Objective: We sought to investigate the rate of and the potential meaning of high AFP serum levels in men seeking first medical attention for couple's primary infertility.
Purpose: Overall, male factor infertility (MFI) accounts for up to 50% of etiologies of couple's infertility, with almost 30% of MFI cases being idiopathic in nature. Idiopathic MFI does not support a tailored treatment work-up in clinical practice. To investigate rates of and characteristics of men presenting for idiopathic unexplained primary infertility as compared with same-ethnicity, age-comparable fertile men.
View Article and Find Full Text PDFBackground: Penile prosthesis implantation has been associated with overall good functional outcomes. Of relevance, some patients reported higher level of satisfaction and quality of life.
Aim: We investigated the profile of the patients who may benefit the most from penile prosthesis implantation.
Background: In 2021, the World Health Organization (WHO) has provided the latest update on processing and evaluating semen analysis.
Objectives: To assess (i) the rate of discordance in semen parameters categorization across three different WHO reference values (namely WHO21, 2010 and 1999) and (ii) the clinical differences among discordant semen analyses from a cohort of primary infertile men.
Materials And Methods: Data from 788 infertile men were analyzed.
Background: Erectile dysfunction aetiology has been historically identified as organic, psychogenic and mixed.
Objectives: To stratify and compare a cohort of patients seeking medical help for erectile dysfunction for the first time according to the newly proposed binary classification of the European Association of Urology guidelines: 'primary organic' versus 'primary psychogenic'.
Materials And Methods: Complete data from 2009 consecutive patients presenting for erectile dysfunction were analysed.
A range of drugs have a direct role in triggering ischaemic priapism. We aimed at identifying: a) which medications are associated with most priapism-reports; and, b) within these medications, comparing their potential to elicit priapism through a disproportionality analysis. The FDA Adverse Event Reporting System (FAERS) database was queried to identify those drugs associated the most with priapism reports over the last 5 years.
View Article and Find Full Text PDFA limited number of studies have described patients on finasteride showing findings which were consistent with Peyronie's disease (PD). We aimed to detect a pharmacovigilance signal of possible association between finasteride and PD-related clinical features. The Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database was queried to identify the ten drugs which were associated the most with the adverse drug reactions (ADRs) recorded as "penile curvature" and/or "Peyronie's disease".
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