Effectiveness and safety of intravenous valproate in agitation: a systematic review.

Rationale: The use of intravenous valproate is not approved for clinical practice in psychiatry. Literature data pointed out for a potential usefulness of this route of administration for valproate, but there is no actual consensus.

Objectives: The aim of the present systematic review is to assess the effectiveness of intravenous valproate in agitation as well as general safety.

Workplace Violence and Burnout Among Mental Health Workers.

Objective: The authors conducted a cross-sectional survey to investigate the association between episodes of patient aggression and burnout among mental health professionals.

Methods: Scores of the Maslach Burnout Inventory (MBI) among 183 participants who completed a questionnaire on violence exposure were used as the outcome. Demographic and work-related variables were examined as potential moderators of the association between aggression and burnout.

Number of illness episodes as predictor of residual symptoms in major depressive disorder.

Notwithstanding major depressive disorder (MDD) is a recurring and chronic condition, relatively few variables have consistently been shown to predict its course. Residual depressive symptoms may be associated with disability and functional impairment but few studies evaluated clinical correlates associated with these symptoms and their impact on functioning after adjustment for potential confounders. Therefore, our study aimed to investigate factors associated with residual depressive symptoms and their impact on the course of MDD.