Publications by authors named "Nicoletta Gastaldo"
Article Synopsis
- Lysyl oxidase (LOX) is crucial for the maturation of the extracellular matrix by forming cross-links in collagen and elastin, and it regulates the promoter activity of both collagen III and elastin.
- The study found that TGF-beta1 activates elastin promoter constructs but inhibits LOX's ability to enhance its activity, while CTGF and basic FGF also showed inhibitory effects on LOX, with distinct mechanisms.
- Analysis of transcription factor binding revealed that LOX alters DNA-protein complexes, primarily inhibiting TGF-beta1-regulated complexes, indicating a complex interplay between LOX and TGF-beta1 through specific transcription factors like SMAD and AP1.
