Automated segmentation and prediction of intervertebral disc morphology and uniaxial deformations from MRI.

Objective: The measurement of intervertebral disc (IVD) mechanics may be used to understand the etiology of IVD degeneration and low back pain (LBP). To this end, our lab has developed methods to measure IVD morphology and uniaxial compressive deformation (% change in IVD height) resulting from dynamic activity, , using magnetic resonance images (MRI). However, due to the time-intensive nature of manual image segmentation, we sought to validate an image segmentation algorithm that could accurately and reliably reproduce models of tissue mechanics.

NLRP7 inter-domain interactions: the NACHT-associated domain is the physical mediator for oligomeric assembly.

Mutations in NLRP7 (NOD-like-receptor family, pyrin domain containing 7) are responsible for a type of recurrent pregnancy loss known as recurrent hydatidiform mole (HYDM1). This condition is characterized by abnormal growth of the placenta, a lack of proper embryonic development and abnormal methylation patterns at multiple imprinted loci in diploid biparental molar tissues. The role of NLRP7 protein in the disease manifestation is currently not clear.

Physical activity, health, and dietary patterns of middle school children.

Purpose: We sought to characterize the physical activity, health, and dietary patterns of middle school children and examine associations between these factors. Parent-child relationships also were examined.

Methods: Thirty-eight children and parents participated and completed a three-day physical activity recall and 24-hour dietary recall.