An hypoxia-tolerant flatfish: consequences of sustained stress on the slender sole Lyopsetta exilis (Pleuronectidae) in the context of a changing ocean.

Slender sole Lyopsetta exilis is an abundant groundfish on the continental shelf and inner waters of British Columbia, Canada, where it reaches a maximum standard length of 44 cm. Benthic image surveys coupled with oxygen measurements in Saanich Inlet document a dense population in bottom conditions near anoxia (0.03 ml l oxygen) where diel migrating zooplankton intersect the bottom; we confirm this species is a planktivore, which limits its depth range to the base of the migration layer.

Challenges of creating a one-size-fits-all oncology CPOE application.

Since August 1996, the oncology clinicians at Massachusetts General Hospital (MGH) have been using an in-house developed CPOE system to order chemotherapy for their adult population. While the pediatric chemotherapy ordering remained on paper until November 2003, designing the pediatric chemotherapy functionality into the existing CPOE product proved to be very challenging. It was helpful in one sense because there was an existing framework that was familiar to everyone.