Publications by authors named "Nicole Siparsky"

Article Synopsis
  • - The study examined issues in emergency inter-hospital transfers of severely injured patients, specifically at high-level trauma centers, finding that the re-triage process often takes longer than the recommended two-hour window, which increases mortality risk.
  • - Researchers conducted a thorough analysis involving 64 healthcare professionals to identify failures in the re-triage process, mapping out 178 issues, with the most critical being insufficient transport staff, problems with imaging transmission, and gaps in clinical information exchange.
  • - The study concludes that significant failures in the transfer process stem from inadequate transportation resources and incomplete clinical information sharing, highlighting the need for improvements in these areas to enhance patient outcomes.
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Objective: To describe rates of dexamethasone use in the nonoperative management of malignant small bowel obstruction (mSBO) and their outcomes.

Background: mSBO is common in patients with advanced abdominal-pelvic cancers. Management includes prioritizing quality of life and avoiding surgical intervention when possible.

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Importance: Spanish-speaking participants are underrepresented in clinical trials, limiting study generalizability and contributing to ongoing health inequity. The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) trial intentionally included Spanish-speaking participants.

Objective: To describe trial participation and compare clinical and patient-reported outcomes among Spanish-speaking and English-speaking participants with acute appendicitis randomized to antibiotics.

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Vaginitis emphysematosa (VE) is a rare, benign, and self-limited condition often diagnosed by the presence of intramuscular vaginal air observed on computed tomography (CT) scan. Although it is a nonpathologic, self-limited condition requiring no intervention, it is important to rule out a more serious infectious pathology. This report highlights a clinical dilemma and the potential consequences of over-reliance on CT in distinguishing benign VE from pathologic necrotizing vaginitis.

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Successful shared decision-making for critically ill intensive care unit (ICU) patients requires bidirectional communication. Through observation of ICU conversations, our study aimed to identify communication skill deficiencies in providers who care for patients in the ICU. This was an observational prospective study performed in a single urban academic medical center (671 beds) from June 2021 through August 2021.

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Importance: A patient's belief in the likely success of a treatment may influence outcomes, but this has been understudied in surgical trials.

Objective: To examine the association between patients' baseline beliefs about the likelihood of treatment success with outcomes of antibiotics for appendicitis in the Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) trial.

Design, Setting, And Participants: This was a secondary analysis of the CODA randomized clinical trial.

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Objective: To compare secondary patient reported outcomes of perceptions of treatment success and function for patients treated for appendicitis with appendectomy vs. antibiotics at 30 days.

Summary Background Data: The Comparison of Outcomes of antibiotic Drugs and Appendectomy trial found antibiotics noninferior to appendectomy based on 30-day health status.

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Article Synopsis
  • The CODA trial found that outpatient management of acute appendicitis using antibiotics is a safe and effective alternative to immediate surgery, with about 50% of participants discharged within 24 hours.
  • The cohort study analyzed data from 776 adults with imaging-confirmed appendicitis who received antibiotics and assessed the safety and outcomes of outpatient versus inpatient care.
  • Results indicated that most treated participants managed their appendicitis without needing surgery, and outpatient management could reduce hospital visits, increase convenience, and lower healthcare costs.
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Importance: For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such trials compare with those of patients who select their treatment and whether outcomes differ.

Objective: To compare participants in the Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) randomized clinical trial (RCT) with a parallel cohort study of participants who declined randomization and self-selected treatment.

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Importance: Use of antibiotics for the treatment of appendicitis is safe and has been found to be noninferior to appendectomy based on self-reported health status at 30 days. Identifying patient characteristics associated with a greater likelihood of appendectomy within 30 days in those who initiate antibiotics could support more individualized decision-making.

Objective: To assess patient factors associated with undergoing appendectomy within 30 days of initiating antibiotics for appendicitis.

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Introduction: Skin popping (SP) is a popular technique for drug misuse, for its ease of administration and longer duration of effect. Skin infection is a well-described sequela of SP, but less is known about the more extreme sequelae of this practice.

Methods: Five patients who engaged in SP requiring major surgical intervention were identified on case review to highlight extreme diseases resulting from the practice of SP.

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Background: Chronic pain patients at risk of addiction can be identified through pre-prescription screening with the opioid risk tool (ORT); there is no equivalent for surgical patients. Our aims were to validate the ORT in the surgical population and assess the impact of patient education on compliance with proper storage and disposal (S&D) of unused opioid therapy (UOT).

Methods: Each subject completed the ORT, prevideo and postvideo surveys, educational video viewing, and compliance survey.

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Background: Intraabdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are devastating complications of surgery. Patients who undergo complex ventral hernia repair (CVHR) may be at risk for IAH and ACS.

Methods: We performed a retrospective review of 175 patients who underwent CVHR by a single surgeon.

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Background: The American Association for the Surgery of Trauma (AAST) has developed a new grading system for uniform description of anatomic severity of emergency general surgery (EGS) diseases, ranging from Grade I (mild) to Grade V (severe). The purpose of this study was to determine the relationship of AAST grades for acute colonic diverticulitis with patient outcomes. A secondary purpose was to propose an EGS quality improvement program using risk-adjusted center outcomes, similar to National Surgical Quality Improvement Program and Trauma Quality Improvement Program methodologies.

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