Publications by authors named "Nicole Singer"
Article Synopsis
- Coronary artery disease is a major health issue that significantly contributes to illness and death, with factors like intraplaque hemorrhage playing a key role in plaque development.
- The study focuses on establishing a method to assess the permeability of microvessels in fresh human coronary artery samples using the Evans Blue Dye assay, which had not been previously done.
- The protocol includes steps for perfusion of arteries, sample collection for analysis, and optional use of a mouse model to further investigate vascular permeability in different health conditions.
We present the cardiac findings from the autopsy of a 28-year-old male with mucopolysaccharidosis VII (MPS VII), also known as Sly Syndrome, whose diagnosis was confirmed by biochemical testing. The patient died a sudden cardiac death. Autopsy showed thickened and stenotic aortic valve leaflets as well as marked concentric intimal thickening of the aorta and muscular arteries.
View Article and Find Full Text PDFBackground: Congenital pericardial defects occur from a defect in the formation of the pleuropericardial membrane during embryonic development. This defect may be asymptomatic but can be fatal if complicated by herniation of any portion of the heart.
Cases: We report two cases in which herniation of a portion of the heart occurred through a partial left pericardial defect and resulted in fetal death.