Validation of the ACR-EULAR criteria for primary Sjögren's syndrome in a Dutch prospective diagnostic cohort.

Objectives: To validate the ACR-EULAR classification criteria for primary SS (pSS), and compare them to the American-European Consensus Group (AECG) and ACR criteria in a Dutch prospective diagnostic cohort.

Methods: Consecutive patients (n = 129) referred for suspicion of pSS underwent a multidisciplinary evaluation, including a labial and/or parotid gland biopsy. Patients with an incomplete work-up (n = 8) or associated systemic auto-immune disease (n = 7) were excluded.

Sex differences in clinical characteristics of dry eye disease.

Purpose: To investigate the role of sex on the symptomatology of DED and on the associations between symptoms and signs.

Methods: A cross-sectional study was used including 755 dry eye patients from the Groningen Longitudinal Sicca Study (GLOSSY cohort). Patient symptoms were assessed by the Ocular Surface Disease Index (OSDI) questionnaire and dry eye signs by the six most commonly used tests.

Predictors of Discordance between Symptoms and Signs in Dry Eye Disease.

Purpose: To investigate predictors of discordance between symptoms and signs in dry eye disease (DED).

Design: Cross-sectional association study.

Participants: A total of 648 patients with dry eye from the Groningen LOngitudinal Sicca StudY (GLOSSY), a tertiary dry eye clinic patient cohort from the Netherlands.

Clinical Characteristics of Dry Eye Patients With Chronic Pain Syndromes.

Purpose: To investigate clinical characteristics of dry eye disease (DED) patients with a chronic pain syndrome.

Design: Cross-sectional study.

Methods: Four hundred twenty-five patients of a tertiary care DED patient cohort in the Netherlands were included.