A quality by design approach to develop topical creams via hot-melt extrusion technology.

The advantages of hot-melt extrusion technology (HME) over conventional techniques to develop topical semisolids have been established. However, this technique is not widely used for semisolid production. Therefore, the aim of this novel work was to develop creams using the melt extrusion technology while applying Quality by Design (QbD) principles to study the effects of the extrusion process parameters on the product characteristics.

Development of poloxamer gel formulations via hot-melt extrusion technology.

Poloxamer gels are conventionally prepared by the "hot" or the "cold" process. But these techniques have some disadvantages such as high energy consumption, requires expensive equipment and often have scale up issues. Therefore, the objective of this work was to develop poloxamer gels by hot-melt extrusion technology.

Bioadhesive Drug Delivery System for Enhancing the Permeability of a BCS Class III Drug via Hot-Melt Extrusion Technology.

As the buccal route of administration has the ability to avoid the GI tract and first-pass effect by directing the absorption toward the cheek area, the bioavailability of BCS class III drugs can be increased through this route. Only a handful of studies have been conducted using oleic acid as a permeation enhancer in any transbuccal drug delivery system. Therefore, the objectives of this novel study were to develop a buccal tablet using two concentrations of oleic acid for a model BCS class III drug via hot-melt extrusion technology and to investigate the effects of oleic acid on the physicochemical properties of the tablet.