On "intent" in research misconduct.

Research misconduct, broadly defined as acts of fabrication, falsification and/or plagiarism, violate the value system of science, cost significant wastage of public resources, and in more extreme cases endanger research participants or members of the society at large. Determination of culpability in research misconduct requires establishment of intent on the part of the respondent or perpetrator. However, "intent" is a state of mind, and its perception is subjective, unequivocal evidence for which would not be as readily established compared to the objective evidence available for the acts themselves.

Post-publication Peer Review with an Intention to Uncover Data/Result Irregularities and Potential Research Misconduct in Scientific Research: Vigilantism or Volunteerism?

Irregularities in data/results of scientific research might be spotted pre-publication by co-workers and reviewers, or post-publication by readers typically with vested interest. The latter might consist of fellow researchers in the same subject area who would naturally pay closer attention to a published paper. However, it is increasingly apparent that there are readers who interrogate papers in detail with a primary intention to identify potential problems with the work.

Letter to editor: NLP systems such as ChatGPT cannot be listed as an author because these cannot fulfill widely adopted authorship criteria.

This letter to the editor suggests adding a technical point to the new editorial policy expounded by Hosseini et al. on the mandatory disclosure of any use of natural language processing (NLP) systems, or generative AI, in writing scholarly publications. Such AI systems should naturally also be forbidden from being named as authors, because they would not have fulfilled prevailing authorship guidelines (such as the widely adopted ICMJE authorship criteria).

A Review of Scientific Ethics Issues Associated with the Recently Approved Drugs for Alzheimer's Disease.

Alzheimer's disease (AD), the devastating and most prevailing underlying cause for age-associated dementia, has no effective disease-modifying treatment. The last approved drug for the relief of AD symptoms was in 2003. The recent approval of sodium oligomannate (GV-971, 2019) in China and the human antibody aducanumab in the USA (ADUHELM, 2021) therefore represent significant breakthroughs, albeit ones that are fraught with controversy.

Research data mismanagement - from questionable research practice to research misconduct.

Good record keeping practice and research data management underlie responsible research conduct and promote reproducibility of research findings in the sciences. In many cases of research misconduct, inadequate research data management frequently appear as an accompanying finding. Findings of disorganized or otherwise poor data archival or loss of research data are, on their own, not usually considered as indicative of research misconduct.

Wilfully submitting to and publishing in predatory journals - a covert form of research misconduct?

A predatory journal could be provisionally defined as one masquerading as a genuine academic publication but offer little, if any, rigorous peer review. Predatory journals or publishers place a focus on maximising financial profit, as opposed to regulated dissemination of scientific advancements. As a result, authors can often get their work published in such journals with little scrutiny on quality.

Moral obligations in conducting stem cell-based therapy trials for autism spectrum disorder.

Unregulated patient treatments and approved clinical trials have been conducted with haematopoietic stem cells and mesenchymal stem cells for children with autism spectrum disorder (ASD). While the former direct-to-consumer practice is usually considered rogue and should be legally constrained, regulated clinical trials could also be ethically questionable. Here, we outline principal objections against these trials as they are currently conducted.

A research misconduct severity matrix that could serve to harmonize adjudication of findings.

The procedures undertaken to investigate a research misconduct are usually dictated by research ethics and integrity policy, prescribed either by the institute or by the national agency overseeing research. This policy would typically contain information on an investigation should be conducted, as well as a non-exhaustive list of what constitutes research misconduct. Typically lacking from these policies would be a precise prescription of how the degree of severity of research misconduct could be determined.

An alarming retraction rate for scientific publications on Coronavirus Disease 2019 (COVID-19).

The ongoing Coronavirus Disease 2019 (COVID-19) global pandemic has triggered a flurry of associated research publications, numbering to ~137 papers a day since February 2020. This rate of publication appears to be exceptionally high, when compared to research papers published on other similar topics. Searches of COVID-19-associated publications on PubMed and Retraction Watch Database indicate that the retraction record appearance rate for COVID-19-related research is also exceptionally high compared to other related research topics in viral epidemics/pandemics and surpasses the basal level of about 4 in 10,000 papers.

High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve Oncogenesis.

Infection with high-risk human papillomavirus (HPV) has been linked to several human cancers, the most prominent of which is cervical cancer. The integration of the viral genome into the host genome is one of the manners in which the viral oncogenes E6 and E7 achieve persistent expression. The most well-studied cellular targets of the viral oncogenes E6 and E7 are p53 and pRb, respectively.