Investigate Global Chromosomal Interaction by Hi-C in Human Naive CD4 T Cells.

Hi-C is a methodology developed to reveal chromosomal interactions from a genome-wide perspective. Here, we described a protocol for generating Hi-C sequencing libraries in resting and activated human naive CD4 T cells to investigate activation-induced chromatin structure re-arrangement in T cell activation followed by a section reviewing the general concepts of Hi-C data analysis.

Effects of Patellofemoral Taping on Patellofemoral Joint Alignment and Contact Area During Weight Bearing.

Study Design Controlled laboratory study. Background Although it has been theorized that patellofemoral joint (PFJ) taping can correct patellar malalignment, the effects of PFJ taping techniques on patellar alignment and contact area have not yet been studied during weight bearing. Objective To examine the effects of 2 taping approaches (Kinesio and McConnell) on PFJ alignment and contact area.

Prospective multinational study of pertussis infection in hospitalized infants and their household contacts.

Background: Increased incidence of pertussis has been noted among infants too young to be immunized. We studied the disease burden of pertussis in pediatric intensive care units and the source of infection in several Asian, European and Latin American countries.

Methods: The study was conducted in 7 countries from September 2001 to January 2004.

University of Toronto case-control study of multiple chemical sensitivity-3: intra-erythrocytic mineral levels.

Background: Multiple chemical sensitivity (MCS) has an estimated American prevalence of 15%, and no consistently abnormal laboratory tests are available to assist in its diagnosis. Some physicians treating MCS patients have observed changes in intra-erythrocytic minerals (IEMs). As co-factors, minerals could influence detoxication of xenobiotics.

Case-control study of multiple chemical sensitivity, comparing haematology, biochemistry, vitamins and serum volatile organic compound measures.

Background: Multiple chemical sensitivity (MCS), although poorly understood, is associated with considerable morbidity.

Aim: To investigate potential biological mechanisms underlying MCS in a case-control study.

Methods: Two hundred and twenty-three MCS cases and 194 controls (urban females, aged 30-64 years) fulfilled reproducible eligibility criteria with discriminant validity.

Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR.

Background: Impaired metabolism of toxic chemicals is a postulated mechanism underlying multiple chemical sensitivity (MCS). Because genetic variation alters the rate of chemical metabolism, this study was designed to determine if MCS cases differed from controls for genetic polymorphisms in drug-metabolizing enzymes.

Methods: Female Caucasian participants (203 cases and 162 controls) were drawn from a larger case-control study based on a reproducible and validated case definition.

Porous-surfaced dental implants in the partially edentulous maxilla: assessment for subclinical mobility.

Fifty patients received 151 short, porous-surfaced implants in the partially edentulous maxilla. Periotest values (PTV) were recorded at baseline and after 6 months and 1 and 2 years. For this, prostheses were removed and a standard abutment attached and tightened (20-Ncm force) to each implant.