Intravenous antibiotic use and exacerbation events in an adult cystic fibrosis centre: A prospective observational study.

Introduction: In CF, people with higher FEV are less aggressively treated with intravenous (IV) antibiotics, with resultant negative impact on their health outcomes. This could be entirely clinician-driven, but patient choice may also influence IV use. In this prospective observational study, we explored IV recommendations by clinicians and IV acceptance by adults with CF to understand how clinical presentations consistent with exacerbations resulted in IV use.