Sensory irritation caused by two organic solvents-short-time single application and repeated occlusive test in stingers and non-stingers.

Background: Neurosensory irritation is a subjective phenomenon induced by a number of chemicals. Objectives. To investigate the sensory irritation induced by two organic solvents - n-octane and cumene - between two groups of volunteers, stingers and non-stingers, identified as such according to the results of a lactic acid stinging test (LAST).

The lactic acid stinging test predicts susceptibility to cumulative irritation caused by two lipophilic irritants.

Background: Skin exposure to lipophilic irritants at workplaces is a risk factor for the development of occupational irritant hand dermatitis. Suitable lipophilic model irritants to be used in repeated irritation studies in volunteers are needed to gain a better understanding of the chemical-dependent mechanisms of skin irritation.

Objectives: To investigate acute and cumulative irritation elicited by two new lipophilic model irritants, octane (CAS No.