A resident-led initiative to improve patient safety event reporting in an internal medicine residency program.

Background: Despite the Clinical Learning Environment Review's recommendations of their use, patient safety event reporting systems are underutilized by residents.

Objective: We aimed to identify perceived barriers to event reporting amongst internal medicine residents and implement a targeted quality improvement initiative to address the identified barriers and increase overall resident event report rates.

Methods: A total of 94 Internal Medicine (IM) residents participated in the educational intervention in 2018.

Layperson Telepresenters: Increasing Capacity for Telehealth in Underserved Communities.

With numerous advancements in telemedicine over the past few years, there has been a huge shift toward home-based digital care. However, the absence of telepresenters in the home to facilitate these teleconsultations can result in incomplete and insufficient patient assessments, both of which can affect overall health outcomes. We describe the feasibility of training laypersons to serve as telepresenters in a community-based telemedicine setting.

Quality assessment of microarray data in a multicenter study.

Issues implicit in a multicenter microarray study are protocol standardization and monitoring center adherence to established protocols. This study explored the effects of submitting center and sample preservation method on the quality of isolated RNA. In addition, the effects of sample preservation method and laboratory on microarray quality were also examined.

Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses.

Retroviral integration into the host genome is not entirely random, and integration site preferences vary among different retroviruses. Human immunodeficiency virus (HIV) prefers to integrate within active genes, whereas murine leukemia virus (MLV) prefers to integrate near transcription start sites and CpG islands. On the other hand, integration of avian sarcoma-leukosis virus (ASLV) shows little preference either for genes, transcription start sites, or CpG islands.

A comprehensive SNP-based genetic analysis of inbred mouse strains.

Dense genetic maps of mammalian genomes facilitate a variety of biological studies including the mapping of polygenic traits, positional cloning of monogenic traits, mapping of quantitative or qualitative trait loci, marker association, allelic imbalance, speed congenic construction, and evolutionary or phylogenetic comparison. In particular, single nucleotide polymorphisms (SNPs) have proved useful because of their abundance and compatibility with multiple high-throughput technology platforms. SNP genotyping is especially suited for the genetic analysis of model organisms such as the mouse because biallelic markers remain fully informative when used to characterize crosses between inbred strains.

Development of multiplex DNA electronic microarrays using a universal adaptor system for detection of single nucleotide polymorphisms.

The NanoChip electronic microarray is designed for the rapid detection of genetic variation in research and clinical diagnosis. We have developed a multiplex electronic microarray assay, specific for single nucleotide polymorphism (SNP) genotyping and mutation detection, using universal adaptor sequences tailed to the 5' end of PCR primers specific to each target. PCR products, amplified by primers directed to the universal adaptor sequence, are immobilized on the microarray either directly or via capture oligonucleotides complementary to the universal adaptor sequence.