The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology.

Fragments of the TAR DNA-binding protein 43 (TDP43) are major components of intracellular aggregates associated with amyotrophic lateral sclerosis and frontotemporal dementia. A variety of C-terminal fragments (CTFs) exist, with distinct N termini; however, little is known regarding their differences in metabolism and aggregation dynamics. Previously, we found that specific CTFs accumulate in the absence of the Arg/N-end rule pathway of the ubiquitin proteasome system (UPS) and that their degradation requires arginyl-tRNA protein transferase 1 (ATE1).

Concept Analysis of Responsible Sexual Behavior in Adult Women.

The concept of responsible sexual behavior is not clearly defined as it applies to adult women who have sex with men. Responsible sexual behavior is a socially desirable and deliberate pattern of behaviors used to promote sexual health, manage risk, and foster respect for sexual partners within the context of community influences. A purposeful redefinition may be necessary to maintain a concept that is useful and effective for evaluating sexual behavior.

Collegiate Women's Definitions of Responsible Sexual Behavior.

Promoting responsible sexual behavior (RSB) is a public health strategy to decrease unplanned pregnancies and sexually transmitted infections (STIs). Current definitions of RSB in the literature have been developed by providers and policy makers; little is known about adult women's perspectives. Interventions inconsistent with women's definitions of RSB may be less effective; therefore, the purpose of this study was to understand how a sample of college women defined RSB.

Parent Perceptions of Sexual Education Needs for Their Children With Autism.

Unlabelled: Primary responsibility for sexual education for adolescents with autism spectrum disorder falls on parents who have reported a lack of professional and material support. The purpose of this study was to 1) describe parent perceptions of sexual education needs of their children aged 14-20 with an autism spectrum disorder diagnosis and 2) determine parent-preferred mechanisms of delivery for tailored educational intervention strategies.

Design And Methods: The study aims were accomplished by a qualitative research design using focus groups and telephone interviews assisted by a structured interview guide.