Publications by authors named "Nicole Lewin"
is a long noncoding RNA expressed since early specification of thyroid bud and is the most enriched gene in the mouse thyroid primordium at E10.5. Here, we studied its involvement in thyroid carcinogenesis by analyzing its expression in cancer tissues and different models of neoplastic transformation.
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- lncRNAs are becoming increasingly important as regulators of various biological processes, but their diverse mechanisms make them challenging to study, particularly in terms of understanding molecular functions.
- A new lncRNA named Klhl14-AS has been discovered as the most abundant transcript in the developing thyroid of mice, with at least five unique splicing variants identified.
- Klhl14-AS shows varying expression levels across several adult mouse tissues, including thyroid, lung, kidney, and brain, with cell type-specific expression patterns suggesting potential functional roles in different organs.