Publications by authors named "Nicole Kretschmann"
Atrophic brain changes in acute anorexia nervosa (AN) are often visible to the naked eye on computed tomography or magnetic resonance imaging scans, but it remains unclear what is driving these effects. In neurological diseases, neurofilament light (NF-L) and tau protein have been linked to axonal damage. Glial fibrillary acidic protein (GFAP) has been associated with astroglial injury.
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- Analytical platforms using impedance spectroscopy offer a non-invasive way to study single cells and their environment, vital for understanding disease-related functions.
- The newly developed "sensor-in-a-tube" combines rolled-up platinum microelectrodes to analyze human monocytes and their extracellular medium activated by liposaccharides (LPS).
- This innovative sensor successfully detects the relationship between cell activation states and the electrical properties of their surroundings without needing any labeling or surface modifications, making it a valuable tool for diagnosing immune-related diseases.
Profiling individual clinical responses by high-frequency serum neurofilament assessment in MS.
Neurol Neuroimmunol Neuroinflamm
May 2019
Objective: To evaluate individual neurofilament light chain (NfL) variation over the time of disease course and the potential of NfL measurement to predict treatment response in patients with MS.
Methods: We investigated 15 patients with MS after immune reconstitution treatment with alemtuzumab (ATZ). Monthly serum NfL (sNFL) measurements were correlated with Expanded Disability Status Scale (EDSS), MRI, and relapse activity over an observational period of up to 102 months.